Results 171 to 180 of about 29,782 (235)

"The emperor's new clothes": a qualitative study of end users' experiences from a failed large-scale implementation of an electronic health record system. [PDF]

BMC Health Serv Res
Dannapfel P, Axelsson A, Gustavsson SMK.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Identifying healthy and sustainable high-impact eating behaviour in French children aged 6-15 years: a combined multidisciplinary and living lab participatory approach. [PDF]

J Nutr Sci
Fardet A, Planchat-Héry C, Rock E, Bochan L.   +3 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

What Is the Meaning of Patient-Centered Decision-Making for a Middle Nurse Manager?-A Qualitative Study. [PDF]

Nurs Rep
Di Giuseppe V, Gualandi R, Tartaglini D, De Benedictis A, Filomeno L, Popa D, Ivziku D.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A User-Centered Approach to Achieving High Degree of Digital Health Technology Utilization for Community HIV Case Management and Data Collection in Ethiopia. [PDF]

Glob Health Sci Pract
Mekuria LA, Likasa G, Sintayehu T, Mekonen L, Tekeste A, Seid E, Asefa W, Negash A, Shewarega A, Tilaye M, Eyassu G, Belete K, Nur M, Neri S, Hayes A, Liddell E, Mookherji S, Tsegaye DA.   +17 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Leadership and management competencies and practices among health managers in Wakiso District, Uganda. [PDF]

PLoS One
Musoke D, Ssembuusi A, Lubega GB, Niyongabo F, Brown MO, Holder R, Pitchford R, Gibson L.   +7 more
europepmc   +1 more source