Results 181 to 190 of about 1,898,707 (253)

UC2-ESP: A general-purpose framework for open-source microscopy control. [PDF]

J Microsc
Diederich B, Fuchs I, Wang H, Bierhoff H, Kuttke C, Heintzmann R.   +5 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Engaging Choice Architecture: Interventions in the Emergency Medicine Standardized Letter (eSLOE 2.0) to Adjust Rater Behaviors. [PDF]

J Grad Med Educ
Bord S, Franzen D, Karl E, Hegarty CB, Shappell E, Schnapp BH, Dubosh NM, Schrepel C, Hiller KM, Hamilton K, House J, Pelletier-Bui A.   +11 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Global literature review and survey of implementation constraints on natural climate solutions. [PDF]

Nat Commun
Kroeger T, Erbaugh JT, Luo Z, Brumberg H, Eichhorst W, Hegwood M, LoPresti A, Shyamsundar P, Ellis PW, Oakes LE, Martin D, Brancalion PHS, Bourne M, Jagadish A, Austin KG, Kinzer AT, Sanjuán M, McCullough L, Echavarria M.   +18 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Ischaemic strokes as an initial manifestation of eosinophilic granulomatosis with polyangiitis with eosinophilic myocarditis: a case report. [PDF]

Eur Heart J Case Rep
Ley L, Kirsch C, Bandorski D.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source