Results 151 to 160 of about 222,383 (304)

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Observation of t t ¯ $$ t\overline{t} $$ production in the lepton+jets and dilepton channels in p+Pb collisions at s NN $$ \sqrt{s_{\textrm{NN}}} $$ = 8.16 TeV with the ATLAS detector

open access: yesJournal of High Energy Physics
This paper reports the observation of top-quark pair production in proton-lead collisions in the ATLAS experiment at the Large Hadron Collider. The measurement is performed using 165 nb −1 of p+Pb data collected at s NN $$ \sqrt{s_{\textrm{NN}}} $$ = 8 ...
The ATLAS collaboration   +2902 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian   +8 more
wiley   +1 more source

10th International Workshop on Top Quark Physics

open access: yes, 2017
The 10th International Workshop on Top Quark Physics, TOP 2017, will be held in the city of Braga, in Portugal, from September 17th to 22nd. Following the long tradition of the workshop, the communities of experimental and theoretical physicists working ...

core  

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier   +6 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Top Quark Physics

open access: yes, 1999
In this contribution I review the physics of top quarks at a future Linear Collider. Main emphasis is put on the process e+ e- to ttbar close to threshold. Different physical observables, their sensitivity to the basic parameters and their theoretical prediction are discussed.
openaire   +2 more sources

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand   +5 more
wiley   +1 more source

Measurement of the top-quark pole mass in dileptonic t t ¯ $$ t\overline{t} $$ + 1-jet events at s = 13 $$ \sqrt{s}=13 $$ TeV with the ATLAS experiment

open access: yesJournal of High Energy Physics
A measurement of the top-quark pole mass m t pole $$ {m}_t^{\textrm{pole}} $$ is presented in t t ¯ $$ t\overline{t} $$ events with an additional jet, t t ¯ $$ t\overline{t} $$ + 1-jet, produced in pp collisions at s = 13 $$ \sqrt{s}=13 $$ TeV.
The ATLAS collaboration   +2935 more
doaj   +1 more source

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