Results 181 to 190 of about 17,862 (264)

A phase 3 randomized, double-blind, placebo-controlled study of durvalumab in combination with gemcitabine plus cisplatin (GemCis) in patients (pts) with advanced biliary tract cancer (BTC): TOPAZ-1.

Journal of Clinical Oncology, 2022
378 Background: BTC is a rare, heterogenous cancer with poor prognosis. Reports on immunogenic features of BTC suggest checkpoint inhibition may result in antitumor immune responses, and limited clinical activity has been seen with single agents in ...
D. Oh, A. He, S. Qin, Li-Tzong Chen, T. Okusaka, Arndt Vogel, J. W. Kim, Thatthan Suksombooncharoen, Myung-Ah Lee, M. Kitano, H. Burris, Mohamed Bouattour, S. Tanasanvimon, R. Zaucha, A. Avallone, J. Cundom, N. Rokutanda, Julia Xiong, G. Cohen, Juan W. Valle   +19 more
semanticscholar   +1 more source

Characterization of long-term survivors in the TOPAZ-1 study of durvalumab or placebo plus gemcitabine and cisplatin in advanced biliary tract cancer.

Journal of Clinical Oncology, 2023
531 Background: At the primary analysis of TOPAZ-1 (NCT03875235; data cut-off [DCO] Aug 11, 2021), durvalumab (D) + gemcitabine and cisplatin (GC) significantly improved overall survival (OS) vs placebo (PBO) + GC in participants (pts) with advanced ...
Mohamed Bouattour, J. Valle, A. Vogel, J. Kim, Masayuki Kitano, Jen-Shi Chen, H. Burris, R. Zaucha, S. Qin, L. Evesque, D. Zhen, V. Gupta, Joonoh Park, M. Żotkiewicz, N. Rokutanda, G. Cohen, D. Oh   +16 more
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GENETIC SIGNIFICANCE OF VARIATIONS IN THE FACES OF THE SIMPLE FORMS OF TOPAZ CRYSTAL FROM CHAMBER PEGMATITES OF THE KOROSTEN PLUTON (UKRAINIAN SHIELD)

Mineralogical Journal, 2022
Topaz crystal morphology and habit distortion has been studied in various mineral-structural zones of chamber pegmatites of the Korosten pluton, which is located in north-western part of the Ukrainian Shield.
O. Vovk, I. Naumko, V. I. Pavlyshyn
semanticscholar   +1 more source

Irradiation capsule design for neutron coloration of topaz in a WWR-K reactor.

Applied Radiation and Isotopes, 2022
This study justifies irradiation capsule design calculations used for efficient coloring of topaz in a WWR-K reactor. Various radiation screens used for removing thermal and epithermal neutrons and their influence on the activation of the main impurities
A. Akhanov, M. Aitkulov, D. Sairanbayev, Sh Kh Gizatulin, N. Romanova, A. Shaimerdenov, Y. Chikhray, Zh Ualzhanov, T. Zholdybayev   +8 more
semanticscholar   +1 more source

Implications of Sound Velocities of Natural Topaz on the Seismic L‐Discontinuity

Geophysical Research Letters, 2022
Compressional and shear wave velocities of topaz have been measured by ultrasonic interferometry in a multi‐anvil apparatus up to 13 GPa at room temperature. By fitting the measured velocities under pressure to finite strain equations, the elastic moduli
Si-Bo Chen, N. Cai, Si-Heng Wang, X. Qi, Bao-Sheng Li   +4 more
semanticscholar   +1 more source

Beryl as indicator of metasomatic processes in the California Blue Mine topaz-beryl pegmatite and associated miarolitic pockets

Lithos, 2021
Beryl occurs in a wide variety of rare-element pegmatites and has provided significant insights into their evolution. The geochemical signatures of beryl can record igneous and metasomatic processes but rarely could they be studied at the same location ...
C. Pauly, A. Gysi, K. Pfaff, Ian Merkel
semanticscholar   +1 more source

Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer (TOPAZ-1): patient-reported outcomes from a randomised, double-blind, placebo-controlled, phase 3 trial.

The Lancet Oncology
BACKGROUND In the ongoing, randomised, double-blind phase 3 TOPAZ-1 study, durvalumab, a PD-L1 inhibitor, plus gemcitabine and cisplatin was associated with significant improvements in overall survival compared with placebo, gemcitabine, and cisplatin in
H. Burris, T. Okusaka, Arndt Vogel, M. Lee, Hidenori Takahashi, V. Breder, J. Blanc, Jun-He Li, M. Bachini, M. Żotkiewicz, Jayne Abraham, Nikunj Patel, Julie Wang, Muzammil Ali, N. Rokutanda, G. Cohen, D. Oh   +16 more
semanticscholar   +1 more source