Results 61 to 70 of about 17,862 (264)

Numerical simulation on thermal‐hydraulic and thermoelectric characteristics of the TOPAZ‐II reactor core

open access: yesInternational Journal of Energy Research, 2020
Numerical simulation of the Space Reactor Power System is of great importance to reactors development and application in aerospace. In this paper, thermal‐hydraulic and thermoelectric characteristics analysis based on 1/6th full thermionic reactor core ...
Zhi-Wen Dai   +5 more
semanticscholar   +1 more source

Real‐World Validation of the MAGIC‐D Index in Unresectable Biliary Tract Cancer Treated With Durvalumab Plus Chemotherapy

open access: yesCancer Medicine, Volume 15, Issue 11, November 2026.
Real‐world Validation of the MAGIC‐D Index. The MAGIC‐D index was validated using real‐world data from patients with unresectable BTC who received durvalumab‐chemotherapy at Tongji Hospital. The risk stratification ability of the MAGIC‐D index for patient survival was improved after incorporating Ki67 and CA 19‐9.
Tianao Zhan   +9 more
wiley   +1 more source

DIASTOLIC DYSFUNCTION OF THE RIGHT VENTRICLE IN CORONARY HEART DISEASE PATIENTS

open access: yesРоссийский кардиологический журнал, 2017
Aim. Evaluation of the prevalence of the right ventricle diastolic dysfunction (RVDD) in coronary heart disease patients (CHD), and factors associated with its diagnostics. material and methods. Totally, 691 CHD patient included (412 males) at the age 36-
O. G. Arkhipov, A. N. Sumin
doaj   +1 more source

Upfront Comprehensive Genomic Profiling in Advanced Biliary Tract Cancer: Real‐World Implementation and Clinical Outcomes

open access: yesCancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Biliary Tract Cancers (BTCs) are difficult‐to‐treat malignancies with limited therapeutic options and dismal prognosis. Upfront comprehensive genomic profiling (CGP) is recommended for advanced BTC to identify actionable alterations, but its real‐world implementation remains underexplored. Methods In 2019, we implemented upfront CGP
Saskia Hussung   +13 more
wiley   +1 more source

Student at Topaz High School

open access: yes, 1942
Paul Bell. Paul\u27s father was an administrator at Topaz.

core   +1 more source

Permian sedimentary sequence containing analcimolite and authigenic aegirine from the Boskovice Basin (Bohemian Massif, Czechia)

open access: yesThe Depositional Record, Volume 12, Issue 5, November 2026.
The Permian freshwater lacustrine sedimentary sequence rich in analcime, with unusual authigenic aegirine and NaFe3+ clinopyroxene. Product of ashfall directly linked with fossil accumulation (Konzentrat‐Lagerstätte). Abstract The Early Permian freshwater lacustrine sedimentary sequence in the vicinity of Bačov (Czechia) is world‐famous for its rich ...
Jakub Jirásek   +3 more
wiley   +1 more source

Oenological Characteristics of Fermented Apple Musts and Volatile Profile of Brandies Obtained from Different Apple Cultivars

open access: yesBiomolecules, 2020
Volatile profile of spirits is the most important factor, because it can contribute to pleasant flavor. The aim of the study was to determine the impact of dessert apple cultivar used for fermentation on the concentration of volatile compounds in apple ...
Magdalena Januszek   +2 more
doaj   +1 more source

Simulating strategic interactions with AI agents

open access: yesStrategic Management Journal, Volume 47, Issue 11, Page 2932-2958, November 2026.
Abstract Research Summary We explore how Large Language Models (LLMs) can serve as synthetic subjects to inform strategy research. We introduce a framework for designing and running simulated experiments with LLM‐powered agents. We argue that this approach is useful for rapid, low‐cost prototyping of human experiments and for generating novel ...
Matteo Tranchero   +3 more
wiley   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness   +21 more
wiley   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

open access: yesThe FEBS Journal, Volume 293, Issue 21, Page 6481-6500, November 2026.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti   +8 more
wiley   +1 more source

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