Results 61 to 70 of about 17,862 (264)
Numerical simulation of the Space Reactor Power System is of great importance to reactors development and application in aerospace. In this paper, thermal‐hydraulic and thermoelectric characteristics analysis based on 1/6th full thermionic reactor core ...
Zhi-Wen Dai +5 more
semanticscholar +1 more source
Real‐world Validation of the MAGIC‐D Index. The MAGIC‐D index was validated using real‐world data from patients with unresectable BTC who received durvalumab‐chemotherapy at Tongji Hospital. The risk stratification ability of the MAGIC‐D index for patient survival was improved after incorporating Ki67 and CA 19‐9.
Tianao Zhan +9 more
wiley +1 more source
DIASTOLIC DYSFUNCTION OF THE RIGHT VENTRICLE IN CORONARY HEART DISEASE PATIENTS
Aim. Evaluation of the prevalence of the right ventricle diastolic dysfunction (RVDD) in coronary heart disease patients (CHD), and factors associated with its diagnostics. material and methods. Totally, 691 CHD patient included (412 males) at the age 36-
O. G. Arkhipov, A. N. Sumin
doaj +1 more source
ABSTRACT Background Biliary Tract Cancers (BTCs) are difficult‐to‐treat malignancies with limited therapeutic options and dismal prognosis. Upfront comprehensive genomic profiling (CGP) is recommended for advanced BTC to identify actionable alterations, but its real‐world implementation remains underexplored. Methods In 2019, we implemented upfront CGP
Saskia Hussung +13 more
wiley +1 more source
The Permian freshwater lacustrine sedimentary sequence rich in analcime, with unusual authigenic aegirine and NaFe3+ clinopyroxene. Product of ashfall directly linked with fossil accumulation (Konzentrat‐Lagerstätte). Abstract The Early Permian freshwater lacustrine sedimentary sequence in the vicinity of Bačov (Czechia) is world‐famous for its rich ...
Jakub Jirásek +3 more
wiley +1 more source
Volatile profile of spirits is the most important factor, because it can contribute to pleasant flavor. The aim of the study was to determine the impact of dessert apple cultivar used for fermentation on the concentration of volatile compounds in apple ...
Magdalena Januszek +2 more
doaj +1 more source
Simulating strategic interactions with AI agents
Abstract Research Summary We explore how Large Language Models (LLMs) can serve as synthetic subjects to inform strategy research. We introduce a framework for designing and running simulated experiments with LLM‐powered agents. We argue that this approach is useful for rapid, low‐cost prototyping of human experiments and for generating novel ...
Matteo Tranchero +3 more
wiley +1 more source
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness +21 more
wiley +1 more source
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti +8 more
wiley +1 more source

