Results 81 to 90 of about 955,790 (330)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer

Journal of Advanced Research
Background: The incidence of skin cancer is currently increasing, and conventional treatment options inadequately address the demands of disease management.
Jun Liu, Jiaye Lu, Ling Wu, Tingrui Zhang, Junchao Wu, Lisha Li, Zongguang Tai, Zhongjian Chen, Quangang Zhu   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Exploring the Role of mRNA Methylation in Insect Biology and Resistance

Insects
RNA methylation, characterized by modifications such as N6-methyladenosine, 5-methylcytosine, and N1-methyladenosine plays a crucial role in post-transcriptional gene regulation across diverse biological systems.
Jiayang Zhang, Luobin Lin, Botian Huang, Huoxi Liu, Huaqin Li, Wenmei Wu   +5 more
doaj   +1 more source

Rare region effects at classical, quantum, and non-equilibrium phase transitions

, 2006
Rare regions, i.e., rare large spatial disorder fluctuations, can dramatically change the properties of a phase transition in a quenched disordered system.
Alet F Walczak A M Fisher M P A, Andreichenko V B, Barber M N, Behre J, Berche B, Bergstresser T K, Bramson M, Bray A J, Cardy J, Cardy J, Chopard B, Colborne S G W, Dagotto E, Dhar D, Dhar D, Dickison M, Dickman R, Dorovgotsev S N, Dorovgotsev S N, Dotsenko V, Dotsenko V, Dotsenko V S, Fedorenko A A, Fendler B, Goldenfeld N, Grassberger P, Grinstein G, Harris A B, Harris T E, Hertz J, Jain S, Jensen I, Joyce G S, Landau L D, Landau L D, Landau L D, Landau L D, Larkin A I, Larkin A I, Lifshitz I M, Lifshitz I M, Lifshitz I M, Lin Y C, Lloyd R G, Ma S K, Marro J, Mayer I O, Menyhard N, Miranda E, Obukhov S P, Obukhov S P, Sachdev S, Sachdev S Vojta M Fokas A, Schehr G Rieger H, Schmittmann B, Sinai Y G, Stauffer D, Tauber U C, Thomas Vojta, Todo S, Vafek O Beasley M R Kivelson S A, van der Waals J D, Vojta T, Weiss P   +63 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Transungual Delivery of Ciclopirox Is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model

Pharmaceutics, 2019
Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic
Damian Cordoba Díaz, Marta Elena Losa Iglesias, Ricardo Becerro de Bengoa Vallejo, Manuel Cordoba Diaz   +3 more
doaj   +1 more source

Topical imiquimod

Journal of Dermatological Treatment, 2001
In this ever-expanding world of immunologic advancements, Drs Langley and Pearson have undertaken this timely, succinct review of imiquimod. Given its direct actions on monocytes and macrophages, as well as the many diverse cytokine effects that follow from these events, topical imiquimod has already solidly established itself as a successful treatment
G W, Pearson, R G, Langley
openaire   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

, 2021
Yogesh Amgaonkar, Nitin I. Kochar, A. V. Chandewar, Shrikant Bute, Kamlesh Wadher, Milind Umekar   +5 more
openalex   +1 more source