Results 121 to 130 of about 567 (218)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Sequential topological complexity of aspherical spaces and sectional categories of subgroup inclusions. [PDF]
Math AnnEspinosa Baro A +3 more
europepmc +1 more source
Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement
Advanced Science, EarlyView.The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang +7 more
wiley +1 more source
Towards Algebraic n-Categories of Manifolds and Cobordisms [PDF]
Advancements in the study of extended topological quantum field theories have recently relied upon constructing suitable symmetric monoidal $n$-categories whose objects are smooth $m$-dimensional manifolds and whose $k$-morphisms are $(m+k)$-dimensional ...
Romö, Jack Tyler
core
3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species
Advanced Science, EarlyView.ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu +11 more
wiley +1 more source
On Connectedness and Disconnectedness
, 1995 Constant subcategories, in particular connectednesses/disconnectednesses and torsion/torsion-free subcategories, have been largely investigated, namely by Dickson [5], Preuss [12], Arhangel'sk and Wiegandt [2], Tiller [14], Tholen [13], Cassidy, Herbert ...
Clementino, Maria Manuel (Dep. de Matematica, Univ. de Coimbra, 3000 Coimbra (Portugal))
core
Continuous Operators from Spaces of Lipschitz Functions. [PDF]
Results MathBargetz C, Kąkol J, Sobota D.
europepmc +1 more source
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.Nickel–aluminum composite oxide (NiAlOx‐300) derived from NiAl layered double hydroxide showed high activity for hydrogenolysis of various lignin models. Especially, hydrogenolysis of benzyl phenyl ether could be efficiently proceeded at 20°C and 1 MPa H2.
Jinpeng Liang +9 more
wiley +1 more source