Results 51 to 60 of about 136,965 (253)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Feasibility of topological data analysis for event-related fMRI [PDF]
Network Neuroscience, 2019 Recent fMRI research shows that perceptual and cognitive representations are instantiated in high-dimensional multivoxel patterns in the brain. However, the methods for detecting these representations are limited. Topological data analysis (TDA) is a new
Cameron T. Ellis +4 more
doaj +1 more source
Empowering Advanced Parametric Modes Clustering from Topological Data Analysis
Applied Sciences, 2021 Modal analysis is widely used for addressing NVH—Noise, Vibration, and Hardness—in automotive engineering. The so-called principal modes constitute an orthogonal basis, obtained from the eigenvectors related to the dynamical problem.
Tarek Frahi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Classification based on Topological Data Analysis
CoRR, 2021 تحليل البيانات الطوبولوجية (TDA) هو مجال ناشئ يهدف إلى اكتشاف المعلومات الطوبولوجية المخفية في مجموعة البيانات. تم استخدام أدوات TDA بشكل شائع لإنشاء مرشحات وواصفات طوبولوجية لتحسين طرق التعلم الآلي (ML). تقترح هذه الورقة خوارزمية تطبق TDA مباشرة على مشاكل التصنيف متعددة الفئات، حتى مجموعات البيانات غير المتوازنة، دون أي مرحلة أخرى من تعلم الآلة. أنشأت
Rolando Kindelan +3 more
openaire +2 more sources
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Interpretable machine learning for atomic scale magnetic anisotropy in quantum materials
npj Computational MaterialsThe rising demand for digital storage and environmental concerns necessitate ultra-high-density, energy-efficient solutions. Atomic-scale magnets (ASMs) based on transition metal (TM) dimers on defective graphene exhibit promising magnetic anisotropy ...
Jan Navrátil +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source