Results 51 to 60 of about 128,421 (254)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Promises and pitfalls of topological data analysis for brain connectivity analysis
NeuroImage, 2021 Developing sensitive and reliable methods to distinguish normal and abnormal brain states is a key neuroscientific challenge. Topological Data Analysis, despite its relative novelty, already generated many promising applications, including in ...
Luigi Caputi +2 more
doaj +1 more source
Classification based on Topological Data Analysis
CoRR, 2021 تحليل البيانات الطوبولوجية (TDA) هو مجال ناشئ يهدف إلى اكتشاف المعلومات الطوبولوجية المخفية في مجموعة البيانات. تم استخدام أدوات TDA بشكل شائع لإنشاء مرشحات وواصفات طوبولوجية لتحسين طرق التعلم الآلي (ML). تقترح هذه الورقة خوارزمية تطبق TDA مباشرة على مشاكل التصنيف متعددة الفئات، حتى مجموعات البيانات غير المتوازنة، دون أي مرحلة أخرى من تعلم الآلة. أنشأت
Rolando Kindelan +3 more
openaire +2 more sources
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Interpretable machine learning for atomic scale magnetic anisotropy in quantum materials
npj Computational MaterialsThe rising demand for digital storage and environmental concerns necessitate ultra-high-density, energy-efficient solutions. Atomic-scale magnets (ASMs) based on transition metal (TM) dimers on defective graphene exhibit promising magnetic anisotropy ...
Jan Navrátil +3 more
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
On the Bootstrap for Persistence Diagrams and Landscapes
Моделирование и анализ информационных систем, 2013 Persistent homology probes topological properties from point clouds and functions. By looking at multiple scales simultaneously, one can record the births and deaths of topological features as the scale varies.
F. Chazal +5 more
doaj +1 more source
Topological Data Analysis in Natural Language Processing -- A Tutorial
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2023 Topological Data Analysis (TDA) introduces methods that capture the underlying structure of shapes in data. Within the last two decades, TDA has been mostly examined in unsupervised machine learning tasks.
Wlodek Zadrozny
doaj +1 more source
Differentially Private Topological Data Analysis
CoRR, 2023 This paper is the first to attempt differentially private (DP) topological data analysis (TDA), producing near-optimal private persistence diagrams. We analyze the sensitivity of persistence diagrams in terms of the bottleneck distance, and we show that the commonly used Čech complex has sensitivity that does not decrease as the sample size $n ...
Taegyu Kang +3 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source