Results 151 to 160 of about 836,069 (296)

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Topologically Invisible Defects in Chiral Mirror Lattices

Advanced Physics Research
One of the hallmark of topological insulators is having conductivity properties that are unaffected by the possible presence of defects. In this work, by going beyond backscattering immunity and topological invisibility across defects or disorder is ...
Antonin Coutant, Li‐Yang Zheng, Vassos Achilleos, Olivier Richoux, Georgios Theocharis, Vincent Pagneux   +5 more
doaj   +1 more source

An efficient Q-tensor-based algorithm for liquid crystal alignment away from defects

, 2010
We develop a fast and accurate approximation of the normally stiff equations which minimize the Landau–de Gennes free energy of a nematic liquid crystal. The resulting equations are suitable for all configurations in which defects are not present, making
M. Kaczmarek, Daly, Keith R., Kaczmarek, Malgosia, K. R. Daly, G. D'Alessandro, D'Alessandro, Giampaolo   +5 more
core   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Fully Programmable Slow Light Based on a Spinor Representation of Generalized Coupled‐Resonator‐Induced Transparency

Advanced Science, EarlyView.
A programmable coupled‐resonator‐induced transparency (CRIT) platform is proposed, generalizing classical electromagnetically induced transparency (EIT) via a spinor representation. By utilizing dual‐channel gauge fields and universal unitary operations, this architecture enables dynamically engineered, reconfigurable slow‐light bands on a silicon ...
Seungkyun Park, Beomjoon Chae, Hyungchul Park, Sunkyu Yu, Xianji Piao, Namkyoo Park   +5 more
wiley   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Topological constraints on defect dynamics

Physical Review D
Extended objects (defects) in quantum field theory exhibit rich, nontrivial dynamics describing a variety of physical phenomena. These systems often involve strong coupling at long distances, where the bulk and defects interact, making analytical studies challenging.
Andrea Antinucci, Christian Copetti, Giovanni Galati, Giovanni Rizi   +3 more
openaire   +2 more sources

Cation Diffusion‐Mediated Displaced Reaction‐Transformation in Green Steelmaking

Advanced Science, EarlyView.
The removal of O lattice atoms by environmental H2 at the surface of Fe3O4 results in Fe enrichment, driving the inward diffusion of Fe cations into the bulk. Through hopping between unoccupied and initially occupied sites, cation diffusion triggers a spatially displaced reaction‐transformation and drives subsequent dynamic phase transformations and ...
Guangyi Guo, Paul Paciok, Baptiste Bienvenu, Longqi Bai, Barak Ratzker, Marc Heggen, Xuyang Zhou, Dierk Raabe   +7 more
wiley   +1 more source