Results 211 to 220 of about 836,069 (296)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang   +12 more
wiley   +1 more source

Regulating Spin Polarization through Topological Defects in Carbon-Based Metal-Free Catalyst for Enhanced Fenton-Like Activity. [PDF]

open access: yesAdv Sci (Weinh)
Zhong H   +14 more
europepmc   +1 more source

5 Things To Know About Heart Defects

open access: yes
Heart defects are conditions that are present at birth and can affect the structure of a person\u2019s heart and the way it works. Heart defects are common, costly, and critical conditions that affect people throughout their lives.

core  

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

open access: yesAdvanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen   +11 more
wiley   +1 more source

Mott resistive switching initiated by topological defects. [PDF]

open access: yesNat Commun
Milloch A   +13 more
europepmc   +1 more source

Designer Moiré Quantum Materials Enabled by Freestanding Oxide Membranes in Twisted and Hybrid Bilayers

open access: yesAdvanced Science, EarlyView.
Freestanding oxide membranes transform twistronics by enabling deterministic stacking, strain release, and integration with two‐dimensional materials. A unified framework links local atomic registry to structural reconstruction, polar textures, charge modulation, flat bands, and magnetic responses, while identifying the fabrication and characterization
Puneet Kaur, Rahul, Jan‐Chi Yang
wiley   +1 more source

Polaritonic states trapped by topological defects. [PDF]

open access: yesNat Commun
Smirnova D   +9 more
europepmc   +1 more source

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