Results 31 to 40 of about 79,761 (304)

Degree and Neighborhood Degree Sum-based Topological Characteristics of Zosurabalpin: a Novel Drug for Managing Antibiotic-resistant Infection

Scientific Annals of Computer Science
This article is concerned with the topological characterization of the antibiotic Zosurabalpin through the computation of degree and associated neighborhood degree sum-based topological indices.
Shibsankar Das, Virendra Kumar, Jayjit Barman, Modhuleena Mandal, Arti Kumari   +4 more
doaj   +1 more source

Topological degree and quadratic forms

, 1999
The paper presents methods of computing the topological degree, and other related topological invariants, for real polynomial mappings. There is also introduced a new topological invariant, similar to the topological degree (mod2), for mappings on ...
Szafraniec, Zbigniew
core   +1 more source

Topological Descriptors on Some Families of Graphs

Journal of Chemistry, 2021
In view of the successful applications of graph theory, relationships between the biological activity and chemical structure have been developed. One of the popular topics in graph theory is problems relating to topological indices.
Iftikhar Ahmad, Maqbool Ahmad Chaudhry, Muhammad Hussain, Tariq Mahmood   +3 more
doaj   +1 more source

A new result on the existence of periodic solutions for Liénard equations with a singularity of repulsive type

Journal of Inequalities and Applications, 2017
In this paper, the problem of the existence of a periodic solution is studied for the second order differential equation with a singularity of repulsive type x ″ ( t ) + f ( x ( t ) ) x ′ ( t ) − g ( x ( t ) ) + φ ( t ) x ( t ) = h ( t ) , $$x''(t)+f ...
Shiping Lu
doaj   +1 more source

Computation of Revan Topological Indices for Phenol-Formaldehyde Resin

Journal of Mathematics, 2022
Phenol-formaldehyde resin has a wide range of moldings. The phenolic resin retains properties at the freezing point; hence, it is difficult to determine its age.
Muhammad Kamran, Nadeem Salamat, Riaz Hussain Khan, Muhammad Abaid Ullah, Muhammad Shazib Hameed, M. K. Pandit   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Topological Characterization of the Third Type of Triangular Hex-derived Networks

Scientific Annals of Computer Science, 2021
A topological index is a numerical quantity that defines a chemical descriptor to report several physical, biological and chemical properties of a chemical structure. In recent literature, various degree-based topological indices of a molecular structure
Shibsankar Das, Shikha Rai
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source