Results 151 to 160 of about 148,749 (259)

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

Correlating topological indices with physicochemical properties in 15 polycyclic aromatic hydrocarbons. [PDF]

Sci Rep
Huang Z, Zhao J, Jin B, Cao J, Yang Y, Li Z.   +5 more
europepmc   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Developing a QSPR model for Alzheimer's drugs using topological indices and M-polynomial: A computational study. [PDF]

Sci Rep
Akhbari MH, Movahedi F, Zameni M, Shahavi MH.   +3 more
europepmc   +1 more source

A Computational Approach on Acetaminophen Drug using Degree-Based Topological Indices and M-Polynomials

, 2021
Srinivasan Sankarraman, H Wiener, I Gutman, N Trinajsti, I Gutman, S Nikoli, G Kovaevi, A Milievi, N Trinajsti, N Idrees, M Saif, A Sadiq, A Rauf, F Hussain, M Baa, J Horvthov, M Mokriov, A Semaniov-Feovkov, A Suhnyiov, H Afzal, T Fatima, M Javaid, J.-B Liu, M Rehman, S Wang, M Munir, W Nazeer, S Rafique, A Nizami, S Kang, F Deng, X Zhang, M Alaeiyan, A Mehboob, M Farahani, C Warwick, S Mondal, N De, A Pal, B Saragiotto, C Abdel Shaheed, C Maher, E Black, K Khor, D Kennedy, A Chutatape, S Sharma, T Vancaillie, A Demirkol, J Bales, J Nicholson, P Sadler, M Randic, A Balaban, C Roothaan, R Mulliken, X; Li, Y Shi, J Dearden, A Astaneh-Asl, G Fath-Tabar, G Shirdel, H Rezapour, A Sayadi, B Furtula, I Gutman, S Ediz, P Ranjini, V; S; Lokesha, A Usha, A Milievi, S Nikoli, N Trinajsti, A Jahanbani, H Shooshtary, M Fansury, Rinurwati, F Manso, H Scatena, R Bruns, A Rubira, E Muniz, Y Hu, X Li, Y Shi, T Xu, B Bollobas, P ; Erdos, D Ami, D Belo, B Lui, S Nikoli, N Trinajsti, Z Dvok, B Lidick, R krekovski, B Zhou, N Trinajsti, B Zhou, W Luo   +99 more
openalex   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

QSAR analysis of drugs using graph based degree based topological indices and regression models. [PDF]

Sci Rep
Mufti ZS, Kabeer A, Almehizia AA, Ganati GA.   +3 more
europepmc   +1 more source

Deformable Eutectic Alloy With Near‐Theoretical Yield Strength via Hierarchical Nanoscale Multiphases and Sessile Defects

Advanced Science, EarlyView.
A CoCrFeNiTa0.4 eutectic high‐entropy alloy achieves a near‐theoretical yield strength of 2.6 GPa with 13.6% plasticity. This breakthrough stems from a hierarchical nanostructure (FCC‐Laves lamellae with L12/D022 precipitates), which alleviates the inter‐phase modulus/hardness mismatch through synergistic strengthening and toughening, guiding the ...
Yusha Luo, Qianqian Wang, Bo Sun, Ruixin Sheng, Zhijun Guo, Gaopeng Zou, Zhe Jia, Yang Tong, Gang Sha, Peter K. Liaw, Baolong Shen   +10 more
wiley   +1 more source

Mathematical Modeling of H1-Antihistamines: A QSPR Approach Using Topological Indices. [PDF]

ACS Omega
Manuel M, Angamuthu P.
europepmc   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source