Results 181 to 190 of about 238,661 (277)

Trusses beyond trusses: intertwined and straw-based metamaterials and beyond. [PDF]

NPJ Metamater
Pescialli E, Chen J, Karapiperis K, Ilssar D, Kochmann DM.   +4 more
europepmc   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

Direct Photocurrent Detection of Optical Vortex Based on the Orbital Photo Galvanic Effect: Progress, Challenge, and Perspective

Advanced Science, EarlyView.
Direct orbital angular momentum (OAM) detection through the orbital photogalvanic effect offers a scalable route for integrated optoelectronics. This perspective evaluates symmetry‐driven material selection and demonstrates how electrode matrices enable the resolution of complex, mixed OAM modes.
Jinluo Cheng, Dehong Yang, Weiming Wang, Chang Xu, Zipu Fan, Dong Sun   +5 more
wiley   +1 more source

Guiding Similarity Search in Chemical Fragment Spaces with Weighted Fingerprints. [PDF]

J Chem Inf Model
Lübbers J, Schokolowski M, Lessel U, Weber A, Rarey M.   +4 more
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Non-negative matrix factorization and deconvolution as a dual simplex problem. [PDF]

Genome Biol
Kleverov D, Aladyeva E, Serdyukov A, Artyomov MN.   +3 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Brief comments on "Perturbation response scanning of drug-target networks: Drug repurposing for multiple sclerosis". [PDF]

J Pharm Anal
Giuliani A.
europepmc   +1 more source

Topological spaces [PDF]

Časopis pro pěstování matematiky a fysiky, 1937
openaire   +1 more source