Results 191 to 200 of about 629,691 (304)

Whole Transcriptome Sequencing Analyzes the Interactions of mRNAs and ncRNAs in Cholangiocarcinoma

open access: yesCancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Cholangiocarcinoma is a common hepatic malignant tumor with an unfavorable prognosis. Therefore, we systematically evaluated the transcriptomic landscape of CHOL by whole transcriptome sequencing technology in this study and constructed a ceRNA network associated with CHOL.
Qinlei Wang   +7 more
wiley   +1 more source

A Theory and Model of Scene Representations With Hippocampal Spatial View Cells

open access: yesHippocampus, Volume 35, Issue 3, May 2025.
ABSTRACT A theory and network model are presented of how scene representations are built by forming spatial view cells in the ventromedial visual cortical scene pathway to the hippocampus in primates including humans. Layer 1, corresponding to V1–V4, connects to Layer 2 in the retrosplenial scene area and uses competitive learning to form visual ...
Edmund T. Rolls
wiley   +1 more source

Notes on string topology [PDF]

open access: yesarXiv, 2005
This paper is an exposition of the new subject of String Topology. We present an introduction to this exciting new area, as well as a survey of some of the latest developments, and our views about future directions of research. We begin with reviewing the seminal paper of Chas and Sullivan, which started String Topology by introducing a BV-algebra ...
arxiv  

Topological coordination numbers and coordination reciprocity from electron‐density distributions

open access: yesActa Crystallographica Section A, Volume 81, Issue 3, Page 221-244, May 2025.
An approach is presented to calculate topological coordination numbers (tCNs) obeying the principle of coordination reciprocity from solid angles subtended by the interatomic surfaces of electron density (QTAIM) atomic domains. The tCN approach characterizes a compound's coordination situation as a set of sub‐coordination scenarios with associated ...
Frank R. Wagner   +2 more
wiley   +1 more source

U(N) framed links, three-manifold invariants, and topological strings [PDF]

open access: green, 2003
Pravina Borhade   +2 more
openalex   +1 more source

Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes

open access: yesInternational Journal of Dermatology, Volume 64, Issue 5, Page 870-881, May 2025.
Drug target prediction algorithms based on proteogenomic profiling. Abstract Background The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune‐checkpoint‐based therapies still poses a significant problem.
Indira Pla   +35 more
wiley   +1 more source

The Structural Biology of T‐Cell Antigen Detection at Close Contacts

open access: yesImmunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT T cells physically interrogate their targets using tiny membrane protrusions called microvilli, forming junctions ~400 nm in diameter and ~ 15 nm deep, referred to as “close contacts”. These contacts, which are stabilized by the binding of the small adhesion protein CD2 to its ligand, CD58 and locally exclude large proteins such as the ...
Yuan Lui   +5 more
wiley   +1 more source

Open-Closed TQFT String Operations for Disc Cobordisms, Simultaneous Saddle Interactions, and Constant Homology Classes [PDF]

open access: yesarXiv, 2008
Previously, we showed that most of the open-closed topological quantum field theory (TQFT) string operations vanish including all the higher genus TQFT operations, and we described a small list of genus zero open-closed TQFT string operations which can be nontrivial.
arxiv  

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