Results 71 to 80 of about 10,251 (261)

Midostaurin in daily clinical practice of patients with advanced systemic mastocytosis

British Journal of Haematology, Volume 207, Issue 4, Page 1388-1396, October 2025.
Durable responses based on modified Valent, IWG‐MRT‐ECNM and PPR criteria were predominantly dose‐independent, making dose adjustments due to better tolerability more practicable in daily routine. Gradual tapering of midostaurin, prophylactic treatment with antihistamines and corticosteroids and timely initiation of subsequent therapy can prevent a ...
Johannes Lübke, Nicole Naumann, Timo Brand, Laurenz Steiner, Roland Repp, Georgia Metzgeroth, Alice Fabarius, Wolf‐Karsten Hofmann, Deepti H. Radia, Andreas Reiter, Juliana Schwaab   +10 more
wiley   +1 more source

Pharmacogenetics and personalized medicine : does gender have a role? [PDF]

, 2014
The study of the role of genetic polymorphisms in drug responses, is now a firmly established field of pharmacology research. It has robust applications in predicting drug effect, and therefore contributes to the process of optimum selection of drug and ...
Fenech, Anthony G., Grech, Godfrey
core  

Aszites, Pfortaderthrombose und hepatische Enzephalopathie bei Leberzirrhose: Aktuelle Therapieempfehlungen [PDF]

, 2012
Treatment of Ascites, Portal Vein Thrombosis and Hepatic Encephalopathy in Patients with Cirrhosis of the Liver Background: Ascites, portal vein thrombosis and hepatic encephalopathy are important complications of cirrhosis of the liver.
Abecasis R, Acosta S, Alexander L. Gerbes, Als-Nielsen B, Als-Nielsen B, Amitrano L, Amitrano L, Amitrano L, Arroyo V, Bajaj JS, Bellot B, Bismuth M, Córdoba J, D'Avola D, de Franchis V, DeLeve LD, Fiaccadori F, Francoz C, Francoz C, Gerbes AL, Gerbes AL, Gerbes AL, Gines P, Gluud LL, Gülberg V, Han G, Häussinger D, Luca A, Montagnese S, Prasad S, Rajani R, Rivkin A, Rosemurgy AS, Rossle M, Rössle M, Salerno F, Salerno F, Salerno F, Sanyal AJ, Senzolo M, Tarantino G, Tublin ME, Veit Gülberg, Wong F, Wong F, Zillikens MC, Zocco MA   +46 more
core   +1 more source

DIURETICS IN THE TREATMENT OF CHRONIC HEART FAILURE: FUROSEMIDE OR TORASEMIDE (LITERATURE REVIEW)

Bukovinian Medical Herald
Optimization of diuretic therapy in patients with chronic heart failure (CHF) is a complex problem with many unsolved questions. Diuretics play an important role in the treatment of heart failure. Current guidelines recommend using loop diuretics for the
S. Biletskyi, L. Sydorchuk, O. Petrynych, T. Kazantseva, S. Biletskyi, V.V. Boyko   +5 more
semanticscholar   +1 more source

Evaluation of Bladder Wash as an Alternative Specimen for Postmortem Toxicology: Comparison to Screening Results of Urine and Kidney Tissue

Drug Testing and Analysis, Volume 17, Issue 9, Page 1640-1655, September 2025.
Urine specimens represent the gold standard for screening analyses in forensic toxicology but are not always available postmortem. The current study systematically evaluated bladder wash (BW) as an interesting, but largely unexplored specimen for screening, in comparison to urine and kidney tissue (KT).
Andrea E. Steuer, Lana Brockbals, Sandra N. Poetzsch, Stephan A. Bolliger, Thomas Kraemer   +4 more
wiley   +1 more source

Association of CYP2C9 and SLCO1B1 genetic variants with an effective dose of torasemide in patients with chronic heart failure

Clinical pharmacology and therapy
To study the association of gene polymorphism CYP2С9*2 (rs1799853, c.430C>T, Arg144Cys), CYP2C9*3 (rs1057910, 1075A>C, Ile359Leu) and SLCO1B1*5 (rs4149056, c.521T>C, Val174Ala) with an effective dose of torasemide in patients with chronic heart failure ...
N. Gafurova, R.E. Kazakov, S.S. Murashko, E.V. Shikh   +3 more
semanticscholar   +1 more source

Plasma Ammonia Levels Predict Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt Placement

United European Gastroenterology Journal, Volume 13, Issue 7, Page 1171-1183, September 2025.
ABSTRACT Background Placement of a transjugular intrahepatic portosystemic shunt (TIPS) is an effective treatment for portal hypertension. Overt hepatic encephalopathy (oHE) is a complication after TIPS associated with increased morbidity. Elevated ratio of plasma ammonia (AMM) levels compared to the local upper limit of normal (ULN) has been ...
Lisa Sandmann, Julius F. M. Egge, Anja Tiede, Alena F. Ehrenbauer, Martin A. Kabelitz, Hannah Rieland, Jim B. Mauz, Bernhard C. Meyer, Heiner Wedemeyer, Karin Weissenborn, Benjamin Maasoumy   +10 more
wiley   +1 more source

Exploring safety of down‐titrating diuretics in heart failure management

European Journal of Heart Failure, Volume 27, Issue 8, Page 1393-1399, August 2025.
Event probabilities following down‐titration (), up‐titration (), or no dose change (=). One person represents approximately 10% of cases. Abstract Aims Loop diuretics are widely used in heart failure (HF) for symptom relief. Guidelines advise treating patients with the lowest possible dose of loop diuretics to maintain euvolaemia, based on expert ...
Chrit B.G. Geraeds, Anke Bruninx, Andre L.A.J. Dekker, Arantxa Barandiarán Aizpurua, Inigo Bermejo, Hans‐Peter Brunner‐La Rocca   +5 more
wiley   +1 more source

The potential toxicity of loop diuretics in patients with cardiovascular complications

Journal of Education, Health and Sport, 2018
A patient with cardiovascular complications is a proper candidate for a diuretic treatment. Here, loop diuretics are the drugs with the greatest strength and time of acting, especially when used in urgent cases like exacerbation of heart failure is ...
Grzegorz Liczner, Michał Wiciński, Bartosz Malinowski, Mateusz Ozorowski, Karolina Długi, Sebastian Rewerski   +5 more
doaj   +3 more sources

Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF [PDF]

, 2017
Aims: Elevated serum uric acid concentration (SUA) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders.
Chen, Chen-Huan, Desai, Akshay S., Dukát, Andrej, Jhund, Pardeep S., Kristensen, Søren L., Køber, Lars, Lefkowitz, Martin P., McMurray, John J.V., Mogensen, Ulrik M., Packer, Milton, Prescott, Margaret F., Ramires, Felix, Rouleau, Jean L., Senni, Michele, Shi, Victor C., Solomon, Scott D., Swedberg, Karl   +16 more
core   +3 more sources