Results 121 to 130 of about 4,154,097 (280)
Perceptual Knowledge, Discrimination, and Closure [PDF]
, 2020 Carter and Pritchard (2016) and Pritchard (2010, 2012, 2016) have tried to reconcile the intuition that perceptual knowledge requires only limited discriminatory abilities with the closure principle.
Echeverri, Santiago
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Philosophy Without Belief [PDF]
, 2019 Should we believe our controversial philosophical views? Recently, several authors have argued from broadly conciliationist premises that we should not. If they are right, we philosophers face a dilemma: If we believe our views, we are irrational.
Barnett, Zach
core
Higher-Order Defeat and the Impossibility of Self-Misleading Evidence [PDF]
Evidentialism is the thesis, roughly, that one’s beliefs should fit one’s evidence. The enkratic principle is the thesis, roughly, that one’s beliefs should "line up" with one’s beliefs about which beliefs one ought to have.
Skipper, Mattias
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Evidence, Miracles, and the Existence of Jesus: Comments on Stephen Law [PDF]
, 2014 We use Bayesian tools to assess Law’s skeptical argument against the historicity of Jesus. We clarify and endorse his sub-argument for the conclusion that there is good reason to be skeptical about the miracle claims of the New Testament.
Cavin, Robert Greg +1 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Functional knee positioning in total knee arthroplasty: Rationale and current evidence
Journal of Joint Surgery and ResearchPurpose: This narrative review aimed to evaluate the principles and outcomes of functional knee positioning (FKP) in total knee arthroplasty (TKA), a modern, patient-specific, robot-assisted technique designed to restore native limb alignment while ...
Hannes Vermue +4 more
doaj +1 more source
Contrasting supertree and total-evidence methods: the origin of the pterosaurs [PDF]
, 2008 Benton, Michael J., Hone, David W. E.
core +1 more source