Results 41 to 50 of about 7,196,264 (196)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Pengaruh Quick Ratio, Debt To Total Assets dan Fixed Asset Turnover terhadap Return On Asset

Jurnal Publikasi Ilmu Manajemen
This study aims to analyze the effect of Quick Ratio, Debt to Total Asset, and Fixed Asset Turnover on Return on Asset in chemical sub-sector manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2020–2024 period. The research employed a quantitative approach using secondary data obtained from annual financial statements.
null Siti Melani, null Mia Laksmiwati
openaire   +1 more source

Synergy of Pd Clusters and TiO2 {101} for Photocatalytic Nonoxidative Coupling of Methane

Advanced Science, EarlyView.
This study presents photocatalytic nonoxidative coupling of methane over cal‐Pd0.05/TiO2{101}, achieving near 100% selectivity and long‐term stability under mild flow conditions through synergistic single atoms and clusters catalysis. ABSTRACT Photocatalytic nonoxidative coupling of methane (NOCM) offers a sustainable route to valorize CH4 into C2 ...
Jianlong Yang, Annika S. Tang, Junwang Tang   +2 more
wiley   +1 more source

PENGARUH INVENTORY TURNOVER, TOTAL ASSET TURNOVER DAN CURRENT RATIO TERHADAP PROFITABILITAS PADA PERSEROAN TERBATAS BRIGHT INDONESIA SEED INDUSTRY INTERNATIONAL TBK [PDF]

Skripsi ini dengan judul: “Pengaruh Inventory Turnover, Total Asset Turnover, dan Current Ratio Terhadap Profitabilitas Pada PT BISI International Tbk” ditulis oleh Nama: Mohamad Sururi Maulana, NIM: 126403211015 dengan dibimbing oleh Dr. Ali Mauludi AC,
MOHAMAD SURURI MAULANA, 126403211015
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

PENGARUH INVENTORY TURNOVER, TOTAL ASSET TURNOVER DAN DEBT TO EQUITY RATIO TERHADAP RETURN ON ASSET PERUSAHAAN CONSUMER GOODS YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2019 - 2021

, 2022
Tujuan penelitian ini dilakukan adalah untuk memperoleh bukti empiris mengenai pengaruh dari variabel-variabel independen berupa Inventory Turnover, Total Asset Turnover dan Debt to Equity Ratio terhadap variabel dependen berupa Return on Asset selama
Chou, Andi
core   +1 more source

PENGARUH LEVERAGE, LIKUIDITAS, TOTAL ASSET TURNOVER PADA PROFITABILITAS

Equilibrium: Jurnal Penelitian Pendidikan dan Ekonomi
AbstrakPenelitian ini bertujuan untuk menguji pengaruh leverage, likuiditas, dan total asset turnover terhadap profitabilitas perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) periode 2015-2020. Penelitian ini menggunakan data sekunder berupa laporan keuangan perusahaan manufaktur yang diperoleh dari situs resmi BEI. Teknik pengumpulan
Erlitawati Kaharudin, Anang Tri Wahyono
openaire   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Asset Liquidity and International Portfolio Choice [PDF]

We study optimal portfolio choice in a two-country model where assets represent claims on future consumption and facilitate trade in markets with imperfect credit. Assuming that foreign assets trade at a cost, agents hold relatively more domestic assets.
Athanasios Geromichalos, Ina Simonovska
core