Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Estimating the surface area of birds: using the homing pigeon (Columba livia) as a model
Biology Open, 2014 Estimation of the surface area of the avian body is valuable for thermoregulation and metabolism studies as well as for assessing exposure to oil and other surface-active organic pollutants from a spill.
Cristina R. Perez +2 more
doaj +1 more source
Total body surface area burned and intensive care unit admission greatly influence scar microbiome composition in patients with burns [PDF]
, 2023 Yeongyun Jung +5 more
openalex +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
A single weekly Kt/Vurea target for peritoneal dialysis patients does not provide an equal dialysis dose for all [PDF]
, 2016 Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.Dialysis adequacy is traditionally based on urea clearance, adjusted for total body volume (Kt/Vurea), and clinical guidelines recommend a Kt/Vurea ...
Davenport, Andrew +4 more
core +2 more sources
Abrasive wear behaviour of 27MnB5 steel used in agricultural tines [PDF]
, 2020 Understanding the wear mechanisms in wear parts is a crucial element of tribological investigation, particularly in agricultural applications where the knowledge about abrasive micro-mechanisms of soil engaging tools are limited. In the current research,
De Baets, Patrick +5 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Siteless Survey and Intensive Data Collection in an Artifact-rich Environment: Case Studies from the Eastern Corinthia, Greece [PDF]
, 2006 Archaeological survey in the eastern Mediterranean has become increasingly intensive over the last 20 years, producing greater and more diverse data for smaller units of space.
David K. Pettegrew +2 more
core +1 more source
Journal of Burn Care & Research, 2021 Abstract Burns are routinely assessed at the scene of the incident by prehospital or emergency medical services providers. The initial management of burns is based on the calculation of the extent of the injury, reported as percent total body surface area (TBSA).
Duy P, Tran +5 more
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source