Results 61 to 70 of about 1,024,544 (312)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Statin Use and Benefits of Thyroid Function: A Retrospective Cohort Study

Frontiers in Endocrinology, 2021
PurposePrevious studies have suggested that cholesterol may influence thyroid function. Since statins are widely used for their cholesterol-lowering effect, we aimed to assess the association between statin use and thyroid function, and also to explore ...
Yupeng Wang, Yupeng Wang, Yupeng Wang, Qihang Li, Qihang Li, Qihang Li, Zhongshang Yuan, Shizhan Ma, Shizhan Ma, Shizhan Ma, Shanshan Shao, Shanshan Shao, Shanshan Shao, Yafei Wu, Yafei Wu, Yafei Wu, Zhixiang Wang, Zhixiang Wang, Zhixiang Wang, Qiu Li, Qiu Li, Qiu Li, Ling Gao, Ling Gao, Ling Gao, Meng Zhao, Meng Zhao, Meng Zhao, Jiajun Zhao, Jiajun Zhao, Jiajun Zhao, Jiajun Zhao   +31 more
doaj   +1 more source

Impact of Cholesterol on Voids in Phospholipid Membranes

, 2004
Free volume pockets or voids are important to many biological processes in cell membranes. Free volume fluctuations are a prerequisite for diffusion of lipids and other macromolecules in lipid bilayers.
Almeida, Bassolino-Klimas, Bassolino-Klimas, Bemporad, Berendsen, Berger, Bloom, Bondi, Cantor, Chiu, Cohen, de Jeu, Eckenhoff, Essman, Falck, Galla, Hofsäß, Hoshen, Höltje, Jedlovszky, Jedlovszky, Kaznessis, Lindahl, Loison, Marrink, Marrink, Marrink, Mathai, McConnell, Mitragotri, Nagle, Newman, Patra, Patra, Polson, Pralle, Rajagopal, Repáková, Róg, Shinoda, Smondyrev, Tieleman, Vist, Xiang   +43 more
core   +1 more source

High-intensity interval training combined with vibration and dietary restriction Improves body composition and blood lipids in obese adults: a randomized trial [PDF]

, 2018
This study aimed to compare the effect of high-intensity interval training (HIIT) with additional whole-body vibration (WBV) on body composition and lipid profile in obese/overweight adults on a hypocaloric diet.
López Lluch, Guillermo, Muñoz, Tamara, Pozo Cruz, Jesús del, Sañudo Corrales, Francisco de Borja, W. Davison, Gareth   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Sex differences in the associations between birthweight and lipid levels in middle-age: findings from the 1958 British birth cohort [PDF]

, 2008
Objective To examine sex differences in birthweight–lipid associations. Methods and results Using prospectively collected data on birthweight and non-fasting lipid levels at age 44–45 y from the 1958 British birth cohort (3603 men and 3583 women ...
Cooper, R., Power, C.
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

تقييم دور انزيم ارجنين دي امينيز وعلاقته مع نشوء داء السكري لدى مرضى الكبد الدهني غير الكحولي [PDF]

مجلة ابحاث كلية التربية الاساسية
شملت الدراسة النتائج المستحصلة من فحص (160) عينة من مصل الدم لمجموعتين مجموعة السيطرة والتي شملت (80) عينة، ومجموعة مرضى الكبد الدهني غير الكحوليNAFLD والتي تضمنت (80) عينة حيث قسمت المجاميع حسب العمر الى فئتين عمريتين تضمنت (اقل من 45) و( اكثر من 45 ...
سكينة رشيد, هالة عبدالله   +1 more
doaj   +1 more source

Associations of lipid profiles with the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis of prospective cohort studies

Frontiers in Cardiovascular Medicine, 2022
Background and purposeThe associations of lipid profiles with the risk of ischemic stroke (IS) or hemorrhagic stroke (HS) are controversial. In this study, we aimed to illustrate the optimal level for lipid levels in the risk of IS and HS.Materials and ...
Xiaoxian Gong, Luowei Chen, Bo Song, Xiang Han, Weihai Xu, Bo Wu, Feng Sheng, Min Lou   +7 more
doaj   +1 more source

Correlation of total cholesterol and protein in urine in patients with the nephrotic syndrome [PDF]

, 1980
The excretion of protein and cholesterol in 24 h urine was measured in 42 patients with the nephrotic syndrome.
Jüngst, Dieter, Karl, Hans Josef, Wallner, J.   +2 more
core   +1 more source