Results 71 to 80 of about 1,024,544 (312)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Investigation of \u3cem\u3ede novo\u3c/em\u3e cholesterol synthetic capacity in the gonads of goldfish (\u3cem\u3eCarassius auratus\u3c/em\u3e) exposed to the phytosterol beta-sitosterol [PDF]

, 2006
Total and intra-mitochondrial gonadal cholesterol concentrations are decreased in fish exposed to the phytoestrogen beta-sitosterol (beta-sit). The present study examined the potential for beta-sit to disrupt de novo cholesterol synthesis in the gonads ...
Drolet, Melissa, MacLatchy, Deborah L., Sharpe, Rainie L.   +2 more
core   +1 more source

Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome [PDF]

, 1987
The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis.
Appel, Baxter, Baxter, Chopra, De Mendoza, Eggstein, Felts, Gherardi, Gherardi, Havel, Jüngst, Jüngst, Kashyap, Klahr, Lopes-Virella, Newmark, Ohta, Röschlau, Sachs, Sata, Tamm, Wada, Weichselbaum   +22 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea

Lipids in Health and Disease, 2019
Background Previous studies reported that stature is inversely related to the risk of cardiovascular disease. However, there is limited evidence on the association between height and lipid profiles.
Mi Yeon Lee, Ga Eun Nam, Kyungdo Han, Da Hye Kim, Yang Hyun Kim, Kyung Hwan Cho, Yong Gyu Park   +6 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Determination of cholesterol absorption in man by intestinal perfusion

Journal of Lipid Research, 1977
In this study a technique is described for estimating net absorption of total cholesterol (endogenous + exogenous) that enters the intestine. The method employs intubation of patients with a 3-lumen tube that contains a 10-cm mixing segment in the ...
S M Grundy, H Y Mok
doaj   +1 more source

Serum cholesterol levels, HMG-CoA reductase inhibitors and the risk of intracerebral haemorrhage. the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) [PDF]

, 2016
Objective: Although a concern exists that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) might increase the risk of intracerebral haemorrhage (ICH), the contribution of these agents to the relationship between serum cholesterol and ...
Agnelli, Giancarlo, Azzini, Cristiano, Bonaiti, Silvia, Bonifati, Domenico Marco, Bovi, Paolo, Calabrò, Rocco Salvatore, Cavallini, Anna, Chiti, Alberto, Ciccone, Alfonso, Colombi, Marina, Costa, Paolo, De Gaetano, Giovanni, De Giuli, Valeria, De Vito, Alessandro, Del Sette, Massimo, Del Zotto, Elisabetta, Delodovici, Maria Luisa, Di Castelnuovo, Augusto, Gamba, Massimo, Gandolfo, Carlo, Grassi, Mario, Iacoviello, Licia, La Spina, Paolo, Lanari, Alessia, Lodigiani, Corrado, Malferrari, Giovanni, Marcello, Norina, Marcheselli, Simona, Martini, Giuseppe, Micieli, Giuseppe, Morotti, Andrea, Musolino, Rossella, Paciaroni, Maurizio, Padovani, Alessandro, Pezzini, Alessandro, Poli, Loris, Pugliese, Nicola, Ritelli, Marco, Sessa, Maria, Silvestrelli, Giorgio, Tassi, Rossana, Tomelleri, Giampaolo, Toriello, Antonella, Vandelli, Laura, Zedde, Marialuisa, Zini, Andrea   +45 more
core   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Effectiveness of Food Cholesterol Detect (FCD) Application on Total Cholesterol Levels of Hypercholesterolemia Patients

Jurnal Ilmu dan Teknologi Kesehatan
High cholesterol levels will cause blockages in blood vessels so that circulation is disrupted. The incidence of hypercholesterolemia is still quite high. The Food Cholesterol Detect application is one of the screening tools that can be used to determine
Terati Terati, Yunita Nazarena, Ahmad Shadiq   +2 more
doaj   +1 more source