Results 61 to 70 of about 8,585,164 (342)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Effects of different sources of dietary chromium on meat quality and amino acid content of broilers
浙江大学学报. 农业与生命科学版, 2013 Chromium as a beneficial element was occasionally indicated by more and more investigations reported. Trivalent chromium Cr (Ⅲ) has been accepted as an essential element for 30 years which can affect the growth performance, carcass characteristics, pork ...
TANG Lihua +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
HeliyonThere is an increasing need for fast and reliable analytical methods for the determination of chemical forms of elements in environmental samples. The interest in chromium is driven by the fact that its toxicity depends on its oxidation state.
Jerry Dikobe +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Critical Level of Chromium for Rice in Different Soil Type
Jurnal Ilmu Lingkungan, 2023 The increasing number of industries and poor treatment of waste will damage environmental health, including agricultural land. Agricultural products from contaminated soil may contain hazardous heavy metals such as chromium which can be harmful to human ...
Hidayatuz Zu'amah +4 more
doaj +1 more source
Chromium in food products [PDF]
, 2012 Chromium plays an important role in human and animal bodies. According to the oxidation state chromium can be advantageous for human health and, simultaneously possesses toxic properties.
Pawlak, Anna, Sykuła, Anna
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
PLoS ONE, 2015 Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzymes ...
Weiwei Feng +10 more
doaj +1 more source