Results 241 to 250 of about 44,462 (291)

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Resolving a Nearly Two-Centuries-Old Mystery: On the Structural Chemistry and Physicochemical Properties of Compounds Associated With the Term Ammelide. [PDF]

Chemistry
Koller TJ, Witthaut K, Pritzl RM, Endraß SMJ, Rösch M, Krach G, Lammer N, Klapötke TM, Schnick W.   +8 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

HMGN2 deficiency drives DLBCL progression through impaired R-loop formation and PI3K-AKT hyperactivation. [PDF]

J Transl Med
Zhong J, Tan J, He Y, Xu Y, Chen C, Luo J, Zhang C, Xiong D.   +7 more
europepmc   +1 more source

A multi layered encryption framework using intuitionistic fuzzy graphs and graph theoretic domination for secure communication networks. [PDF]

Sci Rep
Meenakshi A, Dhanushiya S, Mrsic L, Kalampakas A, Samanta S.   +4 more
europepmc   +1 more source

A special machine for solving NP-complete problems. [PDF]

Fundam Res
Xu J, Yu L, Yang H, Ji S, Wu P, Zhang Y, Yang A, Li Q, Li H, Zhu E, Shi X, Shao Z, Leng H, Liu X.   +13 more
europepmc   +1 more source

Evaluating a Novel Method to Limit Non-Target Mortality in Attractive Toxic Sugar Bait Systems. [PDF]

Insects
Kim D, Shine LC, Stenn TMS, Wilson BC, Caragata EP, Alto BW, Burkett-Cadena ND.   +6 more
europepmc   +1 more source

Mindfulness-Based Art Interventions for Students: A Meta-Analysis Review of the Effect on Anxiety. [PDF]

Behav Sci (Basel)
Zhu Z, Xiao L, Ahmad NA, Roslan S, Burhanuddin NAN, Gao J, Huang C.   +6 more
europepmc   +1 more source

De Novo Multi-Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning. [PDF]

Adv Sci (Weinh)
Li X, Gong H, Wang Y, Zhao Y, Li L, Bao P, Kong Q, Fu J, Wan B, Zhang Y, Zhang J, Ni J, Han Z, Nan X, Ju K, Sun L, Ma Y, Chang H, Zheng M, Yu Y, Yang X, Zuo X, Wang H, Li Y.   +23 more
europepmc   +1 more source