Results 41 to 50 of about 21,015 (221)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Regulating a Firm under Adverse Selection and Moral Hazard in Uncertain Environment

Abstract and Applied Analysis, 2014
This paper investigates a problem of how to regulate a firm which has private information about the market capacity, leading to adverse selection, and which can increase the market demand by exerting costly effort, resulting in moral hazard.
Jing Feng, Yanfei Lan, Ruiqing Zhao
doaj   +1 more source

Improved Predictive Control in Multi-Modular Matrix Converter for Six-Phase Generation Systems

Energies, 2020
Distributed generation systems are emerging as a good solution as part of the response to the world’s growing energy demand. In this context multi-phase wind generation systems are a feasible option.
Sergio Toledo, Edgar Maqueda, Marco Rivera, Raúl Gregor, Pat Wheeler, Carlos Romero   +5 more
doaj   +1 more source

Performance investigation of modular multilevel inverter topologies for photovoltaic applications with minimal switches

Electrical engineering & Electromechanics, 2022
Introduction. In recent years, a growing variety of technical applications have necessitated the employment of more powerful equipment. Power electronics and megawatt power levels are required in far too many medium voltage motor drives and utility ...
E. Parimalasundar, N. M. G. Kumar, P. Geetha, K. Suresh   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

On the Benefits of Model Predictive Control for Cascaded-H-Bridge-Fed IPMSM Drives Operating at Very-Low Switching Frequency

IEEE Access
This work investigates the technical and economic benefits of finite control set model predictive control for cascaded-H-bridge-fed permanent magnet synchronous motor drives operating at very-low switching frequencies.
Gioacchino Scaglione, Claudio Nevoloso, Giuseppe Sorrentino, Giuseppe Schettino, Nicola Campagna, Antonino Oscar Di Tommaso, Rosario Miceli   +6 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The influences of including solar photovoltaic system on distribution network operation using one of Bahir Dar radial distribution network as a case study based on selected parameters

Cogent Engineering
There are considerable power losses as well as under voltage issues in a distribution network. Utilities can improve this by including solar PV installations into their distribution networks.
Estifanos Abeje Sharew
doaj   +1 more source