Results 151 to 160 of about 29,262,902 (336)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Characterisation of wear particles genarated during accelerated testing of total hip replacement

, 2004
PhDTotal hip replacements have been in use for over 30 years, and have shown great improvement from design to surgery since the first generation of implants were introduced.
Hussain, Azad
core  

A comparison of commercial assays quantifying mature brain-derived neurotrophic factor (mBDNF) and its precursor (pro-BDNF) in human serum

Scientific Reports
Brain-derived neurotrophic factor (BDNF) and its isoforms (pro- and mBDNF) are promising neurobiomarkers. While total serum BDNF levels have been previously validated, the newer isoforms have not. We aimed to identify the most common serum pro- and mBDNF
Alicia Olivas-Martínez, Francisco M. Peinado, Ainhoa Pérez-Cantero, Lydia Espín-Moreno, Andrea Rodríguez-Carrillo, Esther García-Esquinas, Nicolás Olea, Vicente Mustieles, Mariana F. Fernández   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Direct, indirect, and total effect.

, 2019
Direct, indirect, and total effect.
José M. Fernández-Batanero (7288904), José Manuel Aguilar-Parra (3108117), Remedios López-Liria (3108111), Adolfo J. Cangas-Díaz (7288901), Víctor B. Arias (5433299), Miguel A. Mañas (7288907), Rubén Trigueros (7288898)   +6 more
core   +1 more source

Association of maternal multi-metal exposure and dyslipidemia: a study of air pollution on pregnancy outcomes

BMC Pregnancy and Childbirth
Background Exposure to air pollutants, including heavy metals, is a major environmental concern of public health and these environmental toxicants have been associated with pregnancy complications.
Yoon-Young Go, Young Min Hur, Young-Ah You, Sunwha Park, Gain Lee, Rin Chae, Soo-Min Kim, Young Ju Kim   +7 more
doaj   +1 more source

Optimization of Extraction Process of Total Flavonoids from Loquat Leaves and Its Protective Effect on H9C2 Cells in Hypoxia Injury

Journal of Pharmacy and Bioallied Sciences
To study the reflux extraction process of total flavonoids from loquat leaves and to investigate its protective effect on H9C2 cells in hypoxia injury. An orthogonal test was utilized to optimize the reflux extraction process parameters, Na2S2O4 was used
Zhongcheng Ke, Xiaoling Cheng, Manting Zhao, Xu Cheng, Ting Ye, Ziyang Cheng   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The features of waveguides from hyperbolic metamaterials and topological insulators

Учёные записки Казанского университета: Серия Физико-математические науки, 2018
The refraction and reflection phenomena occurring at the boundaries of dielectric waveguides manufactured from the unusual materials have been discussed.
A.I. Maimistov, E.I. Lyashko
doaj