Results 191 to 200 of about 29,262,902 (336)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Medication burden, adherence and health-related quality of life in COPD in China: a multilevel health system study. [PDF]

BMJ Public Health
Ma X, Li X, Shi C, Wang Y, Li W, Liu L.
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Experimental and Finite Element Studies of Acetabular Cement Pressurisation and Socket Fixation in Total Hip Replacement

, 1997
PhDWith time, the rate of symptomatic acetabular component loosening accelerates and overtakes that of the femoral component as the principal reason for the revision of total hip replacement.
New, Andrew Michael Raymond
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Enhanced pre-clinical assessment of total knee replacement using computational modelling with experimental corroboration & probabilistic applications

, 2009
Demand for Total Knee Replacement (TKR) surgery is high and rising; not just in numbers of procedures, but in the diversity of patient demographics and increase of expectations.
Strickland, Anthony Michael
core  

The association between adolescents' recreational screen exposure and academic performance and its mediating mechanisms. [PDF]

Front Public Health
Zhao J, Zhao J.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Effect of Total Sleep Deprivation on the Cognitive and In-Game Performance of Rocket League Esport Players

Tim D Smithies,1,2 Adam J Toth,1– 4 Mark J Campbell1– 4 1Department of Physical Education & Sport Sciences, University of Limerick, Castletroy, Limerick, Ireland; 2Lero the Science Foundation Ireland Research Centre for Software, University of Limerick ...
Smithies TD, Campbell MJ, Toth AJ
core  

Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?

, 2013
Includes abstract.Includes bibliographical references.Pharyngocutaneous fistula is a common complication of total laryngectomy. We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous ...
Stephenson, Katherine Anna
core