Results 111 to 120 of about 1,149,119 (338)

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Estimating Electron Precipitation using the Total Radiation Belt Electron Content

open access: yes, 2022
In the near-Earth space environment charged particles, mainly electrons and protons, are heavily influenced by Earth's magnetic field and can be captured for years and more. The number of particles with trapped trajectories accumulates over time to create regions of high-intensity radiation that are known as the Van Allen radiation belts.
openaire   +2 more sources

Polarization-induced Rashba spin-orbit coupling in structurally symmetric III-Nitride quantum wells

open access: yes, 2006
The effective linear coupling coefficient and the total spin-splitting are calculated in Ga- and N- face InGaN quantum wells. Alloy content, geometry, and gate voltage affect an internal field and an electron density distribution in the growth direction ...
Litvinov, V. I.
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Positive and negative ionospheric disturbances prior to the 2016 christmas earthquake in Chile

open access: yesGeomatics, Natural Hazards & Risk, 2019
Global ionospheric maps (GIMs) provided by the Center for Orbit Determination in Europe (CODE) served to analyze ionospheric disturbances prior to the December 25, 2016 earthquake in Chile.
C. Sotomayor-Beltran
doaj   +1 more source

Long‐term trends in the total electron content

open access: yesGeophysical Research Letters, 2017
AbstractThe total electron content (TEC) is important among others for Global Navigation Satellite Systems/GPS signal propagation and applications. However, there is only one comprehensive analysis of TEC trends, and the resulted trends are not consistent with trends in other ionospheric parameters. Here we use the TEC data of Lean et al.
Jan Lastovicka   +2 more
openaire   +1 more source

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