Results 141 to 150 of about 23,969,272 (337)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Functional knee positioning in total knee arthroplasty: Rationale and current evidence
Journal of Joint Surgery and ResearchPurpose: This narrative review aimed to evaluate the principles and outcomes of functional knee positioning (FKP) in total knee arthroplasty (TKA), a modern, patient-specific, robot-assisted technique designed to restore native limb alignment while ...
Hannes Vermue +4 more
doaj +1 more source
Districtly Speaking: Evenwel v. Abbott and the Apportionment Population Debate [PDF]
, 2016 The Equal Protection Clause of the Fourteenth Amendment, as interpreted by the Supreme Court, promises substantial equality of population within state legislative districts under the “one-person, one-vote” rule.
Herman, Joey
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Total evidence phylogenies: the missing data issue
, 2014 Long version (12 minutes) of my presentation at Evolution Conference 2014 in Raleigh (Ernst Mayr Symposium) 12 minutes ...
openaire +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Reserves’ influence on South Africa’s total domestic debt: evidence from GFECRA
Cogent Economics & FinanceThis research tackles a gap in existing literature by offering empirical insights into the effectiveness of utilizing the Gold and Foreign Exchange Contingency Reserve Account (GFECRA) in overseeing total domestic debt, thereby enhancing our ...
Eugene Msizi Buthelezi
doaj +1 more source
Stock Prices, Total Factor Productivity and Economic Fluctuations; Some Further Evidence from Japanese and U.S. Sectoral Data [PDF]
Stock Prices - Total Factor ...
Franck Portier, Paul Beaudry
core