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The delivery of ionizing radiation to lymph nodes, thymus and spleen while non-lymphoid organs are shielded has profoundly immunosuppressive effects that may have value in transplantation and the treatment of autoimmune disorders. Here Shimon Slavin reviews what is known of the cellular consequences of total lymphoid irradiation in animals and ...
J J, Solovera, M C, FariƱas
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Total lymphoid irradiation by itself can produce sufficient immunosuppression to prolong the survival of a variety of organ allografts in experimental animals. The degree of prolongation is dose-dependent and is limited by the toxicity that occurs with higher doses.
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Dosimetry for total body irradiation
Radiotherapy and Oncology, 1990Basic dosimetry as well as patient dosimetry are considered. The following items concerning the basic beam dosimetry are discussed: dosimetry calibration, phantom material, beam quality and depth dose measurements in TBI conditions. Dose to the patient should be specified to the midplane of the abdomen but dose to the lung should be estimated for each ...
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Total lymphoid irradiation in renal transplantation
World Journal of Surgery, 1986AbstractTotal lymphoid irradiation (TLI), used in the treatment of some patients with Hodgkin's disease, produces profound immunological changes. In small rodents, mice and rats, a modified version of TLI results in transplantation tolerance for skin and heart allografts. The concept has been expanded to large outbred animals.
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