Results 201 to 210 of about 7,176,390 (296)

Augmented Reality-Guided Individualized Total Knee Arthroplasty: Initial Clinical Implementation and Results. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Dossett HG, Stickels M, Desai R, Kozak A, Shanahan B, Tummala S.   +5 more
europepmc   +1 more source

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

Treatment approaches for equine subchondral lucencies: Clinical considerations and therapeutic decision‐making

Equine Veterinary Education, EarlyView.
Summary Subchondral lucencies, also referred to as subchondral cystic lesions or osseous cyst‐like lesions, are radiographically identifiable defects of subchondral bone that remain an important cause of lameness and reduced athletic performance in horses.
C. Salazar‐Latorre, R. Salcedo‐Jiménez, M. Masri‐Daba   +2 more
wiley   +1 more source

Total Knee Arthroplasty in Alkaptonuric Patient With Ochronotic Arthropathy. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Michalak P, Buchcic P, Drobniewski M, Borowski A.   +3 more
europepmc   +1 more source

Changes in Hypertrophic Synovium Status in Adult Patients With Severe Hemophilia A Receiving Emicizumab Prophylaxis: The RESOLVE Study

Haemophilia, EarlyView.
ABSTRACT Background Evidence on the impact of emicizumab on joint health, particularly hypertrophic synovium (HS), remains limited. Objectives To evaluate changes in HS, using point‐of‐care ultrasound and clinical examination in People with Haemophilia (PwH) switching from replacement therapy to emicizumab.
Matteo Nicola Dario Di Minno, Erminia Baldacci, Ilenia Lorenza Calcaterra, Guido D'Errico, Cristina Santoro, Alessandra Strangio, Silvia Sorella, Marzia Leotta, Rita Carlotta Santoro   +8 more
wiley   +1 more source

Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review

Haemophilia, EarlyView.
ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson, Roy Khalife, Kelsey Uminski   +2 more
wiley   +1 more source

Second-Knee C-Reactive Protein After 1-Week Staged Bilateral Total Knee Arthroplasty. [PDF]

Orthop Surg
Lee J, Kim DS.
europepmc   +1 more source

Utility of the Clinical Frailty Scale, Charlson Comorbidity Index and ACS NSQIP Surgical Risk Calculator in major lower limb orthopaedic surgery

Internal Medicine Journal, EarlyView.
Abstract Background With major lower limb orthopaedic surgery performed in increasingly older and comorbid patients, accurate risk prediction is essential to guide perioperative management and shared decision‐making. Aims To compare the Clinical Frailty Scale (CFS), Charlson Comorbidity Index (CCI) and the American College of Surgeons National Surgical
Alexa Yao, Emily Schembri, Ejoy Zhang, Raphael Hau, Christopher Fong   +4 more
wiley   +1 more source

Robotic-Assisted Total Knee Arthroplasty in HIV-Positive Patients: Precision Surgery for a Changing Epidemic. [PDF]

Orthop Rev (Pavia)
Senyolo I, Elebo N, Geldenhuys DB, Mukiibi W, Sikhauli N, Pietrzak JRT.   +5 more
europepmc   +1 more source