Machine Learning-Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation. [PDF]
JMIR AIKakraba S +5 more
europepmc +1 more source
Clinical Oral Implants Research, EarlyView.ABSTRACT Objectives To evaluate the clinical performance of two‐piece zirconia implants with screw‐retained abutments compared to titanium implants after 1 year of loading. Materials and Methods In this multicenter, prospective, randomized clinical trial, 61 two‐piece zirconia and 61 titanium implants were placed and restored with single crowns ...
Marc Balmer +5 more
wiley +1 more source
A prospective randomized open-label trial of sirolimus versus paclitaxel-coated balloons for the side branch of <i>de novo</i> coronary bifurcation lesion. [PDF]
J Thorac DisGao Q +12 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aim Eloralintide (LY3841136) is a potent, long‐acting selective amylin receptor agonist currently under development for the treatment of obesity with once‐weekly subcutaneous dosing. Materials and Methods This 12‐week Phase 1, randomised, placebo‐controlled, participant‐ and investigator‐blinded, multiple ascending dose study evaluated the ...
Shobha Bhattachar +8 more
wiley +1 more source
A large dataset of labelled single tree point clouds, QSMs and tree graphs. [PDF]
Sci DataGriese N, Ritzert M, Nölke N.
europepmc +1 more source
Do Major Customers Affect Firms' Environmental, Social and Governance Activities?
European Financial Management, EarlyView.ABSTRACT We examine the role of major customers in shaping firms' environmental, social and governance (ESG) practices. We find that firms with major customer relationships undertake fewer ESG activities compared to those without such ties. The association is attenuated when institutional ownership is high, firms are less diversified, customers exhibit
Feng Dong +4 more
wiley +1 more source
Bridge Deformation Monitoring Combining 3D Laser Scanning with Multi-Scale Algorithms. [PDF]
Sensors (Basel)Tan D, Li W, Tao Y, Ji B.
europepmc +1 more source
Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss
Equine Veterinary Journal, EarlyView.Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez +6 more
wiley +1 more source
Oxygen isotopic evidence that Gale crater, Mars, was home to an Early Hesperian water reservoir that underwent significant evaporation. [PDF]
Proc Natl Acad Sci U S AHofmann AE +16 more
europepmc +1 more source
Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective
The FEBS Journal, EarlyView.Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska +5 more
wiley +1 more source