Results 251 to 260 of about 133,754 (301)

Comparison of immunotherapy based total neoadjuvant therapy or standard neoadjuvant chemoradiation for locally advanced rectal cancer: a multi-institutional retrospective study. [PDF]

Front Immunol
Zhao W, Gao W, Du J, Li D, Liu X, Chang Z, Chen P, Sun X, Zhao Y, Jiao H, Wan X, Dong G.   +11 more
europepmc   +1 more source

Does Total Neoadjuvant Therapy Impact Surgical Precision in Total Mesorectal Excision? A Nationwide Survey of the Experiences of Expert Surgeons. [PDF]

Cancers (Basel)
Jäger T, Zitt M, Riss S, Presl J, Schredl P, Neureiter D, Ramspott JP, Tschann P, Brunner W, Nehoda H, Pressl G, Rohregger K, Sucher R, Jenic G, Heuberger A, Kafka-Ritsch R, Tschmelitsch J, Schabl L, Dornauer I, Dermuth F, Rokitte K, Singhartinger F, Holzinger J, Königsrainer I, Emmanuel K, Aigner F.   +25 more
europepmc   +1 more source

Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Insights from the Western Australian Context. [PDF]

Diseases
Oey O, Lin CP, Khattak MA, Ferguson T, Theophilus M, Tiong SS, Ali S, Khan Y.   +7 more
europepmc   +1 more source

Outcomes associated with total neoadjuvant therapy with non-operative intent for rectal adenocarcinoma. [PDF]

Front Oncol
Asare E, Venner E, Batchelor H, Sanders J, Kunk P, Hedrick T, Hoang S, Reilley M, Le T, Friel C, Janowski EM.   +10 more
europepmc   +1 more source

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Total Neoadjuvant Therapy Significantly Increases Complete Clinical Response

Diseases of the Colon & Rectum, 2022
BACKGROUND: Increased experience with total neoadjuvant therapy for rectal cancer suggests significantly more tumor regression and increased rates of complete clinical response as measured by pathological complete response and clinical complete response.
R Luke, Rettig, Bryce W, Beard, Joan J, Ryoo, Sameer, Kulkarni, Mittul, Gulati, Michael, Tam, Vikram, Attaluri   +6 more
openaire   +2 more sources

Total Neoadjuvant Therapy With Short-Course Radiation: US Experience of a Neoadjuvant Rectal Cancer Therapy

Diseases of the Colon & Rectum, 2022
BACKGROUND: Short-course radiation followed by chemotherapy as total neoadjuvant therapy has been investigated primarily in Europe and Australia with increasing global acceptance. There are limited data on this regimen’s use in the United States, however, potentially delaying implementation ...
William C, Chapman, Hyun, Kim, Philip, Bauer, Bilal A, Makhdoom, Nikolaos A, Trikalinos, Katrina S, Pedersen, Sean C, Glasgow, Matthew G, Mutch, Matthew L, Silviera, Amit, Roy, Parag J, Parikh, Steven R, Hunt   +11 more
openaire   +2 more sources

Total Neoadjuvant Therapy for Operable Pancreatic Cancer

Annals of Surgical Oncology, 2020
Overall survival (OS) for operable pancreatic cancer (PC) is optimized when 4-6 months of nonsurgical therapy is combined with pancreatectomy. Because surgery renders the delivery of postoperative therapy uncertain, total neoadjuvant therapy (TNT) is gaining popularity.We performed a retrospective cohort study of patients with operable PC and compared ...
Rebecca Y, Kim, Kathleen K, Christians, Mohammed, Aldakkak, Callisia N, Clarke, Ben, George, Mandana, Kamgar, Abdul H, Khan, Naveen, Kulkarni, William A, Hall, Beth A, Erickson, Douglas B, Evans, Susan, Tsai   +11 more
openaire   +2 more sources

Neoadjuvant Treatment for Rectal Cancer and Nonoperative Management/Total Neoadjuvant Therapy

Digestive Disease Interventions, 2023
AbstractTreatment of locally advanced rectal cancer remains one of the most challenging in colorectal surgery. It has had an evolving landscape over the past three decades. This review describes the introduction of total neoadjuvant therapy—a term aimed to describe an approach where both systemic chemotherapy and chemoradiation are administered in the ...
Amy Edwards-Murphy, Peter Neary
openaire   +1 more source

Total neoadjuvant therapy: Fact, fantasy, or fallacy?

Surgical Oncology, 2022
Colorectal cancer is the second leading cause of cancer death in the United States for men and women, with an estimated 146,000 new cases per year - a staggering 53,000 patients die each year. Rectal cancer comprises a third of these patients, with a 5-year survival rate of 67%. Management of locally advanced rectal cancer in the U.S.
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Total Neoadjuvant Therapy (TNT) in Rectal Cancer

Current Colorectal Cancer Reports, 2018
This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly discusses future directions. Recent randomized trials evaluating TNT show improved rates of pathologic complete response and patient treatment ...
Sarah J. Stephens, Christopher G. Willett, Manisha Palta, Brian G. Czito   +3 more
openaire   +1 more source