Results 261 to 270 of about 133,754 (301)
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Total neoadjuvant therapy for rectal cancer
Cancer/Radiothérapie, 2018While outcomes for patients with locally advanced disease have improved considerably with combined modality therapy, there is now an emphasis on developing risk-adapted treatment strategies. Moreover, the primary cause of death from locally advanced rectal cancer is related to distant progression, which now exceeds the rate of local failure.
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Total Neoadjuvant Therapy for Pancreatic Cancer—What Is Totality?
JAMA SurgeryThis article discusses the meaning of the word total in relation to total neoadjuvant therapy for pancreatic cancer.
Samuele, Cannas, Charles M, Vollmer
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Total neoadjuvant therapy approach in rectal adenocarcinoma.
Clinical advances in hematology & oncology : H&O, 2021The treatment of locally advanced rectal cancer has improved over the years owing to advancements in surgical techniques and chemoradiation, developing into a multidisciplinary approach that has contributed to markedly reduced rates of local recurrence.
Sandra, Kang, Christina, Wu
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Total neoadjuvant therapy for rectal cancer
Seminars in Colon and Rectal Surgery, 2019Abstract The established standard of care in the treatment of locally advanced rectal cancer is trimodal therapy with neoadjuvant radiation, surgery and adjuvant chemotherapy. While the data supporting neoadjuvant radiation and surgery is well founded, there is little to no evidence that shows a benefit from adjuvant chemotherapy.
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Total neoadjuvant therapy for locally advanced rectal cancer.
Journal of Clinical Oncology, 2017662 Background: Current therapy for locally advanced rectal cancer (LARC) consists of 6 months of perioperative therapy, either with pre-operative chemo-radiotherapy (CRT) and post operative adjuvant chemotherapy (PAC) or total neoadjuvant therapy (TNT) with induction chemotherapy (ICT) followed by CRT then surgery. The aim of our study was to report
Andrea Cercek +19 more
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Total neoadjuvant therapy for locally advanced rectal cancer: a narrative review
Future Oncology, 2023Locally advanced rectal cancer has traditionally been treated with chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, a new strategy, total neoadjuvant therapy, involves the administration of CRT and neoadjuvant chemotherapy with the aim of eradicating micrometastases earlier and achieving greater control of the disease ...
Elías Gomis Sellés +10 more
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Clinical Colorectal Cancer, 2022
With increased therapeutic options in rectal cancer, a central question has become how to tailor therapy to patient preferences to avoid both over and under treatment. Total Neoadjuvant Therapy (TNT), defined as delivering all planned chemotherapy and radiation therapy (RT) before surgery, was developed with the primary goal of improving overall ...
Christopher J. Anker +4 more
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With increased therapeutic options in rectal cancer, a central question has become how to tailor therapy to patient preferences to avoid both over and under treatment. Total Neoadjuvant Therapy (TNT), defined as delivering all planned chemotherapy and radiation therapy (RT) before surgery, was developed with the primary goal of improving overall ...
Christopher J. Anker +4 more
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The conundrum of total neoadjuvant therapy in rectal cancer
Colorectal DiseaseAbstractTotal neoadjuvant therapy (TNT) has fast become the paradigm in the management of rectal cancer. The widespread adoption of this approach across the world, not only for locally advanced cancers but even for cancers that otherwise would not merit chemotherapy, leads both to an increase in treatment‐related toxicity for patients and burdens the ...
Devesh S. Ballal +2 more
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Total Neoadjuvant Therapy in Rectal Cancer
Annals of Surgery, 2020Background:The addition of induction chemotherapy to concomitant neoadjuvant chemoradiation in locally advanced rectal cancer could increase pathological downstaging and act on occult micrometastatic disease, leading ultimately to a better outcome.
Petrelli F +7 more
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Total neoadjuvant therapy in rectal cancer
memo - Magazine of European Medical Oncology, 2022Gudrun Piringer, Alexander De Vries
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