Results 211 to 220 of about 285,483 (304)

Immune dysfunction and food-specific IgG associated erosive oral lichen planus: a two-hit pathogenic model. [PDF]

Front Immunol
Yang Y, Yang L, Liu F, Cheng G, Fang Q.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Epidemiological and virological characteristics of influenza in Zhejiang Province, China: A 15-year surveillance study. [PDF]

Hum Vaccin Immunother
Jin J, Yu Z, Zhu Y, Cao Y, Zhang H, Wang X, Sun J.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Robotic versus laparoscopic TME for rectal cancer: meta-analysis of pathological quality indicators. [PDF]

Tech Coloproctol
Morarasu S, Lunca S, Clancy C, Ong WL, Morpurgo E, Dimofte GM.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Anti-SSA/Ro60kd Antibodies Are Associated With Positive Salivary Gland Biopsy in Sjögren's Syndrome: A Retrospective Exploratory Study. [PDF]

Cureus
Matos Sousa R, Duarte M, Martins AF, Capela C.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Coefficientwise Hankel-total positivity of the row-generating polynomials for the output matrices of certain production matrices

Total positivity of matrices is deeply studied and plays an important role in various branches of mathematics. The aim of this paper is to study the criteria for coefficientwise Hankel-total positivity of the row-generating polynomials of generalized $m$-
Zhu, Bao-Xuan
core  

Sentinel Surveillance-Based Epidemiological Analysis of Foodborne Diseases in Shengsi County, China, 2019-2024. [PDF]

Infect Drug Resist
Chen J, Liu X, Wang H, Su Y, Bao R, Ma L, Zhang H.   +6 more
europepmc   +1 more source