Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
CK7-positive hepatocellular carcinoma represents a distinct subtype: a retrospective cohort study. [PDF]
Liu X, Li J, Yang C, Su Z, Xiang B.
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Clinical Importance of Autoantibodies to SOX10 and Lamin A/C as Potential Biomarkers in Sera From Vitiligo Patients. [PDF]
Kim JH +6 more
europepmc +1 more source
Plasma brain-derived p-Tau217 outperforms other p-Tau species in detecting abnormal brain amyloid in an Asian cohort of older people with cerebrovascular disease burden. [PDF]
Chong JR +7 more
europepmc +1 more source
Post-pandemic resurgence and collapse of <i>Mycoplasma pneumoniae</i> in hospitalized children: a four-year multiplex surveillance study in China. [PDF]
Hu H.
europepmc +1 more source
Trend-based quality assurance of binary urinary antigen tests. [PDF]
Sütterlin S, Larsson AO.
europepmc +1 more source

