Results 121 to 130 of about 530,693 (303)

Outsourcing von Instandhaltungsleistungen, untersucht am Beispiel der Automobilindustrie [PDF]

, 1996
For years the German automobile industry has been facing a growing competition from Japan as well as from the emerging markets. Increasing tendencies towards globalization, an even faster change in customer needs and a stronger contraction of the product
Kroha, Jürgen
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In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

IMPLEMENTASI TOTAL PRODUCTIVE MAINTENANCE (TPM) UNTUK MENINGKATKAN PRODUKTIVITAS PERUSAHAAN DI PT. FIRMENICH AROMATICS INDONESIA (STUDI KASUS : PERUSAHAAN ENCAPSULATED FLAVOR) [PDF]

, 2018
PT. Firmenich Aromatics Indonesia merupakan sebuah perusahaan yang memproduksi Durarome tidak terlepas dari masalah yang berkaitan dengan efektivitas mesin/peralatan yang diakibatkan oleh six big losses.
ANGGIE SETYO UTOMO, 133010228, Edi Gunadi, DS   +1 more
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Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Usulan Penerapan Total Productive Maintenance Untuk Mengurangi Downtime Mesin Wrapping Di PT. Sanbe Farma Unit III. [PDF]

, 2017
PT. Sanbe Farma Unit III is an pharmaceutical company produces infusion as one of its product. In the process of packaging Flipped-off (FO) type of infusion, there is wrapping process done by wrapping machine.
CHEVY HERLI SUMERLI, DS, DINY GUSTINI, 143010295, Edi Gunadi, DS   +2 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Analisis Penerapan Total Productive Maintenance (Tpm) Menggunakan Overall Equipment Efectiveness (Oee) Dan Six Big Losses Pada Mesin Cavitec Di PT. Essentra Surabaya [PDF]

, 2014
PT Essentra Surabaya telah menerapkan Total Productive Maintenance guna meningkatkan efisiensi dan efektivitas Perusahaan manufaktur secara menyeluruh.
Dewi, N. C. (Nadia), Rinawati, D. I. (Dyah)   +1 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Trends in the HIgher Education Labor Force: Identifying Changes in Worker Composition and Productivity [PDF]

, 2009
Higher education is a labor-intensive industry whose primary service, instruction, is delivered by a lecturer, accompanied by administrative support and various other services.
Daniel Bennett
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