Results 131 to 140 of about 8,406,914 (282)

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

USULAN PERBAIKAN SISTEM PENERAPAN TOTAL PRODUCTIVE MAINTENANCE (TPM)

, 2007
Perawatan (maintenance) merupakan cara yang paling efektif untuk mengendalikan keandalan sebuah mesin, karena perawatan dapat mencegah excessive deterioration dari mesin tersebut.
ERVIANI, VINA
core   +1 more source

Evaluation of service conditions of the machines within the furniture joinery

Production Engineering Archives, 2015
The aim of this thesis is to present the operation of machines within the furniture joinery, presentation of the risks for this branch, discussion of quality and technical documentation within the analysed enterprise, characteristics of the Total ...
Łukasz Zalejski, Noga Mariusz, Wojtysiak Marcin, Foszmanowicz Krzysztof   +3 more
doaj  

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Total productive maintenance (TPM) na Gestão Industrial

, 2018
Dissertação submetida à Universidade de Trás-os-Montes e Alto Douro para obtenção do grau de ...
openaire   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Performance Evaluation Of Production Machinery At PT XYZ Using The Total Productive Maintenance (Tpm) Concept

Machine performance measurement is necessary to determine operational effectiveness and identify sources of losses that affect productivity. This study aims to calculate the Overall Equipment Effectiveness (OEE) value and identify the dominant factors causing the low effectiveness of the  (HPP) using a Total Productive Maintenance (TPM) approach ...
Krisna Rahabistara, Indah Apriliana Sari Wulandari   +1 more
openaire   +2 more sources

A CT Lesion Foundation Model for Non‐Invasive Assessment of Hepatocellular Carcinoma Aggressiveness and Prediction of Recurrence Risk

Advanced Science, EarlyView.
A computed tomography lesion foundation model, built by sequential self‐supervised pretraining on generic and hepatocellular carcinoma‐specific lesion images, non‐invasively assesses microvascular invasion and pathological grade from contrast‐enhanced CT and stratifies postoperative recurrence risk.
Wei Xia, Zhehan Shen, Mengsi Li, Jianxin Lu, Ji Xia, Yang Cheng, Wenzheng Li, Shunjie Dong, Lin Deng, Ruokun Li   +9 more
wiley   +1 more source

BKV activates the interferon-β response in primary and immortalized microvascular endothelial cells late in the infectious cycle, resulting in persistence. [PDF]

J Virol
Colgan LC, An P, Cantalupo PG, Zheng W, Velasquez AR, Duray AM, Sáenz Robles MT, Weitz D, Pipas JM.   +8 more
europepmc   +1 more source