Results 71 to 80 of about 25,954 (258)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

New Insights Into Changes in the DNA Methylation Pattern of the SHOX Gene in Patients With Léri‐Weill Dyschondrosteosis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SHOX gene haploinsufficiency is associated with Léri‐Weill dyschondrosteosis (LWD) or idiopathic short stature (ISS) and could be caused by the structural and point mutations in the coding region and by the deletions in SHOX gene regulatory sequences. The role of the duplications in regulatory sequences is ambivalent.
Valeriia Kopytko, Katerina Hirschfeldova, Pavlina Capkova, Roman Solc   +3 more
wiley   +1 more source

A Multifaceted Spatial Analysis of Tomb Distribution in Blemmyan Berenike (Eastern Desert of Egypt)

Archaeological Prospection, EarlyView.
ABSTRACT This study examines the spatial and visual organisation of tombs in the post–Roman Berenike located in Egypt's Eastern Desert. Archaeological surveys, remote sensing, geophysical methods, excavations and GIS‐based analyses are used for a comprehensive understanding of the spatial patterns and cultural significance behind the positions and ...
Mariusz Gwiazda, Anna Fijałkowska, Oskar Graszka, Tomasz Herbich, Michał Tyszkiewicz   +4 more
wiley   +1 more source

The Domus Nozze D'Argento in Pompeii: Structural Diagnosis Using Geophysical Methods

Archaeological Prospection, EarlyView.
ABSTRACT Monitoring of ancient buildings is an issue of great interest in view of a proper restoration. This paper describes the noninvasive monitoring of the Domus Nozze D'Argento in Pompeii. The Roman house, as occurred for many other buildings in Pompei, was buried in the ash from the 79 ad eruption of Mount Vesuvius.
Nicola Masini, Maria Sileo, Fabrizio Terenzio Gizzi, Lara De Giorgi, Giovanni Leucci   +4 more
wiley   +1 more source

SARchaeological Prospection: Synthetic Aperture Radar for the Reconstruction and Mapping of Temperate Floodplain Environments

Archaeological Prospection, EarlyView.
ABSTRACT Temperate river floodplains present a significant challenge for archaeologists, as cultural and palaeoenvironmental remains are often difficult to locate but can be exceptionally well preserved, especially where groundwater levels are high. In these alluvial environments, the deposition of thick, fine‐grained sediments has potential to deeply ...
Nicholas Crabb, Chris Carey, Andy J. Howard, Matthew Brolly   +3 more
wiley   +1 more source

Hiding in Plain Sight: Rethinking the Size and Complexity of Iron Age Hillforts in NW Iberia Thanks to Aerial Archaeology and Geophysics

Archaeological Prospection, EarlyView.
ABSTRACT This paper tackles one key limitation in the analysis of Iron Age communities in the Northwestern Iberian Peninsula: the limited exploration of areas beyond the fortified settlements known as castros (hillforts). The vast majority of archaeological studies have focused exclusively on the areas inside the walls of these settlements, which are ...
César Parcero‐Oubiña, Carlos Otero‐Vilariño, María Gómez‐Faro, Jesús Ignacio Jiménez Chaparro, Pastor Fábrega‐Álvarez, Juan Torrejón‐Valdelomar, Marta Crespo‐Fernández, David González‐Álvarez   +7 more
wiley   +1 more source

A Multisensor Remote Sensing Approach to Archaeological Prospection: Integrating UAV and Google Earth Data in the Bayan Gol Valley, Mongolia

Archaeological Prospection, EarlyView.
ABSTRACT This study investigates the effectiveness of drone‐based remote sensing and Google Earth satellite imagery for archaeological prospection in the Bayan Gol Valley, Central Mongolia. Utilizing a fixed‐wing unmanned aerial vehicle (UAV) equipped with RGB and multispectral sensors, we surveyed 655 ha to document Mongol‐period settlement structures
Peter Heimermann, Matthias Lang, Susanne Reichert, Lkhagvadorj Munkhbayar, Jan Bemmann   +4 more
wiley   +1 more source

Upper bounds for domination related parameters in graphs on surfaces

AKCE International Journal of Graphs and Combinatorics, 2016
In this paper we give tight upper bounds on the total domination number, the weakly connected domination number and the connected domination number of a graph in terms of order and Euler characteristic.
Vladimir Samodivkin
doaj   +1 more source

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

Arthritis &Rheumatology, EarlyView.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J. A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

The Geometric Themes in the Mosaics of the Religious Complex of Mértola (Portugal)

Journal of Mosaic Research, 2017
The Settlement of Mértola dates from at least the end of the second or early first millennium BC. In the so-called Iron Age, possibly in the third century BC, a walled enclosure with a total length of about 4 kilometres was constructed.
Virgílio António Martins LOPES
doaj   +1 more source