Results 31 to 40 of about 59,215 (193)

One-loop Modified Gravity in de Sitter Universe, Quantum Corrected Inflation, and its Confrontation with the Planck Result

, 2014
Motivated by issues on inflation, a generalized modified gravity model is investigated, where the model Lagrangian is described by a smooth function $f(R, K, \phi)$ of the Ricci scalar $R$, the kinetic term $K$ of a scalar field $\phi$.
Bamba, Kazuharu, Cognola, Guido, Odintsov, Sergei D., Zerbini, Sergio   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Coupled equations for Kähler metrics and Yang-Mills connections

, 2013
We study equations on a principal bundle over a compact complex manifold coupling a connection on the bundle with a Kahler structure on the base. These equations generalize the conditions of constant scalar curvature for a Kahler metric and Hermite-Yang ...
Garcia-Fernandez, M., García-Prada, O., Álvarez-Cónsul, L.   +2 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

One-loop divergences for $f(R)$ gravity

, 2018
We calculate the divergent part of the one-loop effective action for $f(R)$ gravity on an arbitrary background manifold. Our result generalizes previous results for quantum corrections in $f(R)$ gravity, which have been limited to spaces of constant ...
Ruf, Michael S., Steinwachs, Christian F.   +1 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

On globally static and stationary cosmologies with or without a cosmological constant and the Dark Energy problem

, 2005
In the framework of spatially averaged inhomogeneous cosmologies in classical General Relativity, effective Einstein equations govern the regional and the global dynamics of averaged scalar variables of cosmological models.
Alnes H Amarzguioui M Grøn Ø, Anderson M T, Aubin T, Barrow J D, Bean R Carroll S Trodden M, Bildhauer S, Brandenberger R H, Buchert T, Buchert T, Buchert T, Buchert T Carfora M Shibata M, Buchert T Eriguchi Y, Célérier M-N, Dingle H, Eddington A S, Eddington A S, Ehlers J, Einstein A, Ellis G F R, Ellis G F R, Ellis G F R, Ellis G F R, Ellis G F R Börner G Buchert T Ehlers J Hogan C J Kirshner R P Press W H Raffelt G Thielemann F-K Van den Bergh S Börner G Gottlöber S, Futamase T, Geshnizjani G, Harrison E R, Harrison E R, Ishibashi A, Kolb E W Matarrese S Riotto A, Lehoucq R, Lemaître G, Lemaître G, Lemaître G, Maartens R, Maor I, Moffat J W, Nambu Y Tanimoto M, Peebles P J E, Piazza F, Prigogine I, Räsänen S, Räsänen S, Räsänen S, Schmidt B P, Thomas Buchert, Tolman R C, Uzan J-P, Wiltshire D L, Zalaletdinov R M   +48 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Heat Kernel Expansion on a Cone and Quantum Fields Near Cosmic Strings

, 1993
An asymptotic expansion of the trace of the heat kernel on a cone where the heat coefficients have a delta function behavior at the apex is obtained. It is used to derive the renormalized effective action and total energy of a self-interacting quantum ...
Birrell N D, Cheeger J, Cognola G, D V Fursaev, Davies P C W, De Witt B S, Deser S, Donnelly H, Donnelly H, Dowker J S, Dowker J S, Greiner P, Hawking S W, Kay B S, Kennedy G, Sokolov D D, Sommerfeld A   +16 more
core   +1 more source