Results 221 to 230 of about 2,035,117 (267)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Counting $s$-Catalan words according to total variation

open access: yesEnumerative Combinatorics and Applications
Sela Fried, Mark Shattuck
doaj   +1 more source

Total Generalized Variation

SIAM Journal on Imaging Sciences, 2010
The novel concept of total generalized variation of a function $u$ is introduced, and some of its essential properties are proved. Differently from the bounded variation seminorm, the new concept involves higher-order derivatives of $u$. Numerical examples illustrate the high quality of this functional as a regularization term for mathematical imaging ...
Kristian Bredies   +2 more
openaire   +1 more source

Properties of minimizers of the total variation and of the solutions of the total variation flow

2014 IEEE International Conference on Image Processing (ICIP), 2014
We review some results obtained in collaboration with Vicent Caselles (formerly with DTIC, U. Pompeu Fabra, Barcelona) and Matteo Novaga (U. Pisa) and recent extensions obtained by the first author on the properties of the jump sets of solutions of total variation minimizing problems, including some results on explicit solutions in the 1D and radial ...
Khalid Jalalzai, Antonin Chambolle
openaire   +1 more source

Total Variation in Imaging

2011
The use of total variation as a regularization term in imaging problems was motivated by its ability to recover the image discontinuities. This is at the basis of his numerous applications to denoising, optical flow, stereo imaging and 3D surface reconstruction, segmentation, or interpolation, to mention some of them.
CASELLES V, CHAMBOLLE A, NOVAGA, MATTEO
openaire   +3 more sources

Total Variation Wavelet Inpainting

Journal of Mathematical Imaging and Vision, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tony F. Chan   +2 more
openaire   +2 more sources

On the Total Variation Dictionary Model

IEEE Transactions on Image Processing, 2010
The goal of this paper is to provide a theoretical study of a total variation (TV) dictionary model. Based on the properties of convex analysis and bounded variation functions, the existence of solutions of the TV dictionary model is proved. We then show that the dual form of the model can be given by the minimization of the sum of the l(1) -norm of ...
Tieyong Zeng, Michael K. Ng 0001
openaire   +2 more sources

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