Results 111 to 120 of about 2,326,184 (282)

Upper bound stability analysis of tiered geosynthetic-reinforced soil wall

Journal of Rock Mechanics and Geotechnical Engineering
The tiered geosynthetic-reinforced soil (GRS) walls have been increasingly applied in the high and steep retaining soil structures. However, very little is known about the design method for the tiered GRS wall in practice.
Chengzhi Xiao, Xiangsheng Meng, Shan Gao, Luqiang Ding   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Approximating the total variation distance between spin systems

Spin systems form an important class of undirected graphical models. For two Gibbs distributions $μ$ and $ν$ induced by two spin systems on the same graph $G = (V, E)$, we study the problem of approximating the total variation distance $d_{TV}(μ,ν)$ with an $ε$-relative error. We propose a new reduction that connects the problem of approximating the TV-
Feng, Weiming, Liu, Hongyang, Yang, Minji   +2 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A New Index for Measuring the Non-Uniformity of a Probability Distribution

AppliedMath
This paper proposes a new index, the “distribution non-uniformity index (DNUI)”, for quantitatively measuring the non-uniformity or unevenness of a probability distribution relative to a baseline uniform distribution.
Hening Huang
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A SURVEY ON THREE TROUT FARMS PHOSPHORUS LOADING INTO HARAZ RIVER, NORTH IRAN

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2006
A monthly survey on phosphorous loading due to fish farm sewage was conducted from July 2003 to June 2004 in Haraz River. In total, 88 water samples from eight stations and spots up and down of the three fish farms were sampled.
A. Varedi; F. Vahedi; Y. Olomi; H. Yonesipor; A. Nasrollahtabar
doaj  

Total Variation Distance for Product Distributions is $\#\mathsf{P}$-Complete

We show that computing the total variation distance between two product distributions is $\#\mathsf{P}$-complete. This is in stark contrast with other distance measures such as Kullback-Leibler, Chi-square, and Hellinger, which tensorize over the marginals leading to efficient algorithms.
Bhattacharyya, Arnab, Gayen, Sutanu, Meel, Kuldeep S., Myrisiotis, Dimitrios, Pavan, A., Vinodchandran, N. V.   +5 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source