Results 131 to 140 of about 2,326,184 (282)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Coalescence and total‐variation distance of semi‐infinite inverse‐gamma polymers

Journal of the London Mathematical Society
AbstractWe show that two semi‐infinite positive temperature polymers coalesce on the scale predicted by KPZ (Kardar–Parisi–Zhang) universality. The two polymer paths have the same asymptotic direction and evolve in the same environment, independently until coalescence. If they start at distance apart, their coalescence occurs on the scale . It follows
Firas Rassoul‐Agha, Timo Seppäläinen, Xiao Shen   +2 more
openaire   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Match-to-Match Variation on High-Intensity Demands in a Portuguese Professional Football Team

Journal of Functional Morphology and Kinesiology
The aim of this study was to analyze the match-to-match variation in high-intensity demands from one Portuguese professional football team according to playing positions.
José E. Teixeira, Luís Branquinho, Miguel Leal, Ryland Morgans, Andrew Sortwell, Tiago M. Barbosa, António M. Monteiro, Pedro Afonso, Guilherme Machado, Samuel Encarnação, Ricardo Ferraz, Pedro Forte   +11 more
doaj   +1 more source

Robust estimation for kernel exponential families with smoothed total variation distances

Information Geometry
Abstract In statistical inference, we commonly assume that samples are independent and identically distributed from a probability distribution included in a pre-specified statistical model. However, such an assumption is often violated in practice.
Takafumi Kanamori, Kodai Yokoyama, Takayuki Kawashima   +2 more
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Genetic diversity analysis of wild tea plant resources in Chongzuo based on phenotypic traits and SSR molecular markers.

PLoS ONE
To explore the genetic diversity of wild tea plants, the methods of the phenotypic traits and SSR molecular marker analysis were adopted to analyze the 40 samples of 7 wild tea populations in Chongzuo, Guangxi.
Zongyou Wei, Feifei Wu, Hongyu Feng, Ziping Li, Qinhao Jian, Yunxiong Zhao, Baogui Liu, Jinting Li   +7 more
doaj   +1 more source