Results 131 to 140 of about 22,999 (216)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

Design and implementation of a phasor measurement unit using a new measurement technique. [PDF]

open access: yesSci Rep
Mohamed SA   +5 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang   +11 more
wiley   +1 more source

Peritectic engineering enhanced thermoelectrics for smart thermal messaging devices. [PDF]

open access: yesNat Commun
Xin J   +14 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

open access: yesAdvanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak   +6 more
wiley   +1 more source

Thin‐Film Transistor Based Active Taxel for Multimode Tactile Perception and Fused Processing

open access: yesAdvanced Science, EarlyView.
Skin serves as the largest‐area organ for human and embodied intelligent robots, providing tactile interaction. An active multimode fused (AMF) artificial skin is developed using standard TFT processes, featuring 2T‐1C taxels with optical and electrostatic capacitive receptors for cross‐modal sensing.
Sihao Wu   +13 more
wiley   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

open access: yesAdvanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung   +39 more
wiley   +1 more source

Closed-loop tactile-visual interactivity via chip-free luminescent fibers enabled by capacitive coupling. [PDF]

open access: yesSci Adv
Wu XE   +13 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy