Results 71 to 80 of about 512,873 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Developing storytelling for tour guide to build global branding in Desa Wisata Jajar Gumregah

open access: yesJournal of Community Service and Empowerment
Trenggalek has more than 30 tourist villages that have been intensively built since 2020, including Desa Wisata Jajar Gumregah. This village was chosen as one of the 300 best tourism villages in Anugerah Desa Wisata (ADWI) 2023.
Dwi Wahyuningtyas   +5 more
doaj   +1 more source

Teacher Who Can Really Speak Well Of Himself - Multi lingual tour guide inspired him many years ago [PDF]

open access: yes, 2008
Years ago, K.A.S Annadural went on a school trip to penang and met a tour guide who could speak 10 ...
The Star, Wani Muthiah
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

“The Boss” Critera: Tour Guides’ Competencies from the Perspective of an American Tour Operator - Rick Steves

open access: yesTrakya University Journal of Social Sciences
Türkiye aims to host 80 million visitors in 2028 and become one of the three most visited countries in the world. Tour guiding services may contribute to achieving Türkiye’s goals in tourism.
Burak Düz
doaj   +1 more source

A guided tour of tour guiding

open access: yes, 2004
This has been my second summer as the IOT Tour Coordinator, last time it was in 2002. I took a summer off from this, and there were lots of changes. The building is bigger, the staff has changed a little bit, there is even a new DG. Some things are the same. People here are easy to get along with, there is a new batch of work term students that are fun
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Longstreet’s Attack from Seminary Ridge to the Rose Woods

open access: yes, 2017
This is an overview of a theoretical tour at Gettysburg focusing on Longstreet’s attack on the second day from Seminary Ridge to the Rose Woods. The three tour stops are the Mississippi Monument on West Confederate Avenue, the Peach Orchard, and photos ...
Connelly, Caitlin T.
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Learning to Be a Good Tour-Guide Robot [PDF]

open access: yes, 2011
Thanks to the numerous attempts that are being made to develop autonomous robots, increasingly intelligent and cognitive skills are allowed. This paper proposes an automatic presentation generator for a robot guide, which is considered one more cognitive
Galán López, Ramón   +1 more
core   +1 more source

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