YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
OPTIMIZING THE TOUR GUIDE'S PROVISION OF INFORMATION THROUGH ONLINE MEDIA
Darmabakti CendekiaBackground: Tour guides play a crucial role during a vacation. Tour guides do more than only provide information about the tourist spots seen; they also educate foreign tourists who visit an area. The number of travel agents supplying guidance is growing,
Irwan Yulianto +3 more
doaj +1 more source
Study of the Interpreting Techniques used by the Tourist Guides in the Tourism Attractions of North Sumatra [PDF]
International Journal of English Language and Translation Studies, 2017 Many techniques have been applied in the interpretation and translation in the field of tourism guiding. This research paper focuses on the interpreting techniques of tour guides in North Sumatra.
Bambang Panca Syahputra +3 more
doaj
ENHANCING USERS’ EXPERIENCE WITH SMART MOBILE TECHNOLOGY [PDF]
, 2015 The aim of this thesis is to investigate mobile guides for use with smartphones. Mobile guides have been successfully used to provide information, personalisation and navigation for the user.
Haji Matyassin, Haji Mohammad Alimin +1 more
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
The Relationship Between Fear of COVID-19 and Psychological Distress in Tour Guides: The Mediating Role of Job Insecurity and the Moderating Role of Psychological Resilience. [PDF]
Psychol Res Behav Manag, 2023 Jiang Y +6 more
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
The Impacts of Environmental Dynamism on Chinese Tour Guides' Sustainable Performance: Factors Related to Vitality, Positive Stress Mindset and Supportive Policy. [PDF]
Int J Environ Res Public Health, 2022 Sun P, Zhou X, Shao C, Wang W, Sun J.
europepmc +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source