Results 111 to 120 of about 6,177 (210)
Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature
Brain and Behavior, Volume 16, Issue 2, February 2026.Executive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Simone Migliore +4 more
wiley +1 more source
Transgenic mouse models of childhood-onset psychiatric disorders [PDF]
, 2011 Available in PMC 2012 April 1.Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect ...
Feng, Guoping, Robertson, Holly Rochelle
core +1 more source
Cancer Science, Volume 117, Issue 2, Page 511-521, February 2026.A drug repurposing screen for reactive oxygen species (ROS)‐inducing compounds identified Pimozide as a potent anti‐tumor agent in head and neck squamous cell carcinoma (HNSCC) patient‐derived xenograft (PDX) models. Combined treatment with paclitaxel markedly reduced undifferentiated tumor cells.
Shogo Okazaki +12 more
wiley +1 more source
Treatment of ADHD in Tourette’s Syndrome
Pediatric Neurology Briefs, 1995 A double-blind, placebo-controlled study of clonidine (.05 mg 4xd) and desipramine (25 mg 4xd) treatment of attention-deficit hyperactivity disorder (ADHD) behaviors in 34 children with TS + ADHD is reported from the Departments of Neurology and ...
J Gordon Millichap
doaj +1 more source
The Use of Carbamazepine (Tegretol) in Psychiatry and Its Association to Kindling, Temporal Lobe Epilepsy and Psychopathology [PDF]
, 2011 The recent theory of kindling may help to link neurophysiologic, neurotransmitter and neuroanatomic mechanisms important in understanding the neurology of behavior.
Stanch, M.D., James
core +1 more source
Pediatric Neurology Briefs, 2002 The efficacy of methylphenidate (MPH) and clonidine (CLON), alone and in combination, in 136 children with attention deficit hyperactivity disorder (ADHD) and chronic tic disorder, was evaluated in a multicenter, randomized, double-blind clinical trial, and reported by the Tourette Syndrome Study Group from the University of Rochester, NY.
openaire +3 more sources
The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith +4 more
wiley +1 more source
Guanfacine in Comorbid ADHD & Tourette’s Syndrome
Pediatric Neurology Briefs, 1995 An open-label study of guanfacine (1.5 mg/d), an a-adrenergic agonist, in 10 children with TS + ADHD, aged 8 to 16 years, was reported from the Yale University School of Medicine, New Haven, CT, and Johns Hopkins Medical Institutions, Baltimore, MD.
J Gordon Millichap
doaj +1 more source
Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 263-275, February 2026.The incidence of developmental disorders and special educational needs (SEN) provision were investigated, and associations with gestational age and ethnicity were explored, using the Born in Bradford cohort. Birth before full term was associated with increased odds of developmental disorder and/or SEN, which was even demonstrated in early term (37–38 ...
Katherine Pettinger +4 more
wiley +1 more source