Results 131 to 140 of about 29,513 (254)

Dysbiosis and Therapeutic Modulation of the Gut Microbiota in Multiple Sclerosis: A Narrative Review

open access: yesHealth Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Multiple sclerosis (MS) is a persistent autoimmune disease that affects the central nervous system. The etiology of MS is complex, involving a variety of genetic and environmental factors. Mounting evidence suggests that dysbiosis significantly impacts the progression of MS mainly through its direct effects upon the immune ...
Mojtaba Memariani, Hamed Memariani
wiley   +1 more source

Population Pharmacokinetic and Exposure‐Efficacy Analyses of Valbenazine in Patients with Huntington's Disease: Supporting Dose Selection for Chorea Management

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1777-1788, December 2025.
Abstract Valbenazine improved chorea in individuals with Huntington's disease compared to placebo in a phase 3, placebo‐controlled study (KINECT‐HD). Population pharmacokinetics (PK) and exposure–response (E–R) analyses focused on understanding the PK characteristics of valbenazine and its active metabolite, [+]‐α‐dihydrotetrabenazine ([+]‐α‐HTBZ), and
Hoa Q. Nguyen   +5 more
wiley   +1 more source

Levetiracetam as an alternative therapy for Tourette syndrome

open access: yesNeuropsychiatric Disease and Treatment, 2010
MA Martínez-Granero, A García-Pérez, F MontañesDepartment of Pediatrics and Psychiatry, Hospital Universitario Fundación Alcorcón, Madrid, SpainAbstract: Tourette syndrome is a common ...
MA Martínez-Granero   +2 more
doaj  

Study of conditions to evaluate light hypersensitivity in a light–dark box using a mouse model and a mydriatic

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim The pathophysiology and treatment of sensory hypersensitivity remain unclear. This study aimed to identify a simple behavioral analysis device and animal model evaluating glare sensitivity and to test the effects of psychotropic drugs using this device.
Shogo Hirota   +7 more
wiley   +1 more source

Caregiver‐reported meaningful change in functional domains for individuals with developmental and epileptic encephalopathy: A convergent mixed‐methods design

open access: yesDevelopmental Medicine &Child Neurology, Volume 67, Issue 12, Page 1616-1627, December 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16405 This original article is commented on by Patel on pages 1525‐1526 of this issue. Abstract Aim To investigate how caregivers of children with developmental and epileptic encephalopathy and severe developmental impairments describe meaningful change for functional domains and ...
Jenny Downs   +9 more
wiley   +1 more source

European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part I: assessment [PDF]

open access: hybrid, 2021
Natalia Szejko   +17 more
openalex   +1 more source

Shared Genetic Links Between Birth Weight and Developmental‐Behavioral Disorders

open access: yesGenes, Brain and Behavior, Volume 24, Issue 6, December 2025.
These findings support a shared genetic structure between developmental–behavioral disorders and birth weight. The findings also shed light on the pleiotropy between birth weight and developmental–behavioral disorders. ABSTRACT While observational studies have linked birth weight to developmental‐behavioral disorders, establishing genetic correlations ...
Rongyue Sun   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy