Results 181 to 190 of about 1,578,425 (314)

Thinking beyond blood: brain concentrations and brain-blood ratios in postmortem toxicology. [PDF]

J Anal Toxicol
Skov KØ, van der Meer MZ, Nedahl M, Nielsen MKK.   +3 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Toxic Plants Potentially Impacting the Health Status of Livestock in St. Kitts-A Surveillance Study. [PDF]

Toxins (Basel)
Nagy AL, Caloni F, Kemper RT, Lleras SG, Beigh H, DeJean C, Matthew M, Paraschou G.   +7 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Simulation-based evaluation of emergency medicine residents' preparedness for toxic terrorism. [PDF]

Ulus Travma Acil Cerrahi Derg
Sahin AS, Sahin A, Ozer V, Gonenc Cekic O, Akturan S, Delibalta B, Kiernan E, Turhal E, Pasli S, Karaca Y, Imamoglu M, Tatli O, Korkut S.   +12 more
europepmc   +1 more source

National Toxic Substance Incidents Program (NTSIP) 2011 annual report

In 1980, Congress created the Agency for Toxic Substances and Disease Registry (ATSDR) toimplement health-related sections of laws that protect the public from hazardous wastes and environmental spills of hazardous substances.

core  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

The association between toxic leadership behaviors and nurses' career resilience: heterogeneous indirect roles of regulatory focus profiles. [PDF]

Front Psychol
Gu Y, Liu H, Nie T, Li Y, Sun X, Yang R, Qi Y, Guo L, Tong L.   +8 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Skin Toxic Effects and Survival With Enfortumab Vedotin-Pembrolizumab in Advanced Urothelial Carcinoma.

JAMA Netw Open
Thomas Z, Jiang CY, Speck PJ, Crupi E, Moussa MJ, Joseph A, Stender C, Glover M, Johns AC, Gao J, Desai M, Shah AY, Goswami S, Siefker-Radtke A, Karedath AR, Varughese SP, Ren W, Hassanzadeh C, Bree KK, Kamat AM, Guo CC, Pacha O, Patel A, Curry J, Sherry AD, Msaouel P, Campbell MT, Alhalabi O.   +27 more
europepmc   +1 more source