Results 31 to 40 of about 1,034,620 (269)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Cardenolides in the defensive fluid of adult large milkweed bugs have differential potency on vertebrate and invertebrate predator Na+/K+-ATPases

Royal Society Open Science
Aposematic animals rely on diverse secondary metabolites for defence. Various hypotheses, such as competition, life history and multifunctionality, have been posited to explain defence variability and diversity.
P. Rubiano-Buitrago, S. Pradhan, A. A. Aceves, S. Mohammadi, C. Paetz, H. M. Rowland   +5 more
doaj   +1 more source

Starch Nanomaterial as an Effective Biosorbent for the Removal of Toxic Pb (II) Ions from Aqueous Solution: Kinetics and Isotherm Study [PDF]

Journal of Water and Environmental Nanotechnology
In this study, we prepared the starch nanomaterial for the removal of toxic lead ions from aqueous solution. Different characterization techniques like X-ray diffraction, Scanning electron microscopy, Energy dispersive spectroscopy, Transmission electron
Bilal Bhat, Laxmi Dubey, Harendra Sharma
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade

Toxics
Environmental exposures are ubiquitous and play a significant, and sometimes understated, role in public health as they can lead to the development of various chronic and infectious diseases. In an ideal world, there would be sufficient experimental data
Siddhi Desai, Jewell Wilson, Chao Ji, Jason Sautner, Andrew J. Prussia, Eugene Demchuk, M. Moiz Mumtaz, Patricia Ruiz   +7 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

How toxic is toxic? A proposal for wastewater toxicity hazard assessment

Ecotoxicology and Environmental Safety, 2010
Wastewater management receives a great deal of attention with various methods being proposed for discharge hazard estimation via ecotoxicological results. Policy-makers, stakeholders and the general public do not generally possess an adequate level of understanding on this matter, so it is rather hard to answer the question "How toxic is toxic?".
LIBRALATO, Giovanni, AVEZZU', Francesco, VOLPI GHIRARDINI, Annamaria   +2 more
openaire   +3 more sources

Understanding community resilience during the drinking water contamination event on Oahu, Hawaii, 2021–2022: a mixed mode approach

BMC Public Health
Background A petroleum leak into the Joint Base Pearl Harbor-Hickam water system on Oahu, Hawaii in November 2021 contaminated the drinking water of approximately 93,000 users, causing many to relocate for months. Perceptions of health and wellbeing were
Vidisha Parasram, Amanda R. Smith, Michele L. F. Bolduc, Jamie Rayman, Alex Poniatowski, Nicole Mintz, Madeline Jarvis, Alyssa N. Troeschel, Shanna Miko, Krishna Surasi, Charles Edge, Benjamin Gerhardstein, Diana Felton, Maureen F. Orr   +13 more
doaj   +1 more source