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Activation mechanisms to chemical toxicity
Archives of Toxicology, 1987The pathobiology of chemical toxicity may involve "acute lethal injury" (necrosis), "autoxidative injury" (oxygen toxicity), "immunological injury" (neoantigen formation), and malignancy. Toxic chemicals may be activated by reduction, conjugation, radical formation, or oxidation.
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On The Role of Calcium in Chemical Toxicity
1987It is now well established that the toxic effects of a variety of chemicals are mediated by reactive products formed during their biotransformation in the organism. It is equally clear that there exist protective systems which can trap or inactivate toxic metabolites and thereby prevent their accumulation within the tissues and subsequent toxicity ...
S, Orrenius, P, Nicotera
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Direct toxicity assessment of toxic chemicals with electrochemical method
Analytica Chimica Acta, 2009Electrochemical measurement of respiratory chain activity is a rapid and reliable screening for the toxicity on microorganisms. Here, we investigated in-vitro effects of toxin on Escherichia coli (E. coli) that was taken as a model microorganism incubated with ferricyanide. The current signal of ferrocyanide effectively amplified by ultramicroelectrode
Chang, Liu +3 more
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Modification of chemical toxicity by selenium deficiency
Fundamental and Applied Toxicology, 1983Selenium deficiency causes a number of hepatic metabolic alterations in the rat which could lead to changes in chemical toxicity. It causes a decrease in glutathione peroxidase activity, an increase in glutathione S-transferase activity, and an increase in the rate of glutathione synthesis.
R F, Burk, J M, Lane
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Dehydration and Susceptibility to Toxic Chemicals
Archives of Environmental Health: An International Journal, 1973Deprivation of water for 48 hours increased mortality of rats and mice injected with water soluble compounds of lead, antimony, and methacholine chloride but did not greatly alter susceptibility to lipid soluble trichloroethylene, benzene, and parathion.
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Toxic Tort: Chemical Toxicants Perspective
SSRN Electronic Journal, 2012Toxic torts arise in several contexts. People are typically exposed to toxic chemicals from pharmaceuticals, from consumer products, from the environment, in the home, and at work. Most toxic tort cases have arisen either from exposure to pharmaceutical drugs or occupational exposures.
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The Effects of Nutrition on Chemical Toxicity
Drug Metabolism Reviews, 1994PARKE, DV, IOANNIDES, C
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Toxic Chemicals and Processes Wastes
1995Environmental issues, particularly concerned about toxic chemicals and hazardous wastes from industrial processes, are receiving more attention in policy, program and media dimensions in both developed and developing countries. Pollution from toxic chemicals and hazardous wastes is more extensive and difficult to manage than originally believed ...
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Metal–Organic Frameworks against Toxic Chemicals
Chemical Reviews, 2020Cassandra T Buru +2 more
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