Results 171 to 180 of about 524,357 (214)
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Postgraduate Medicine, 1972
Toxic epidermal necrolysis, although uncommon, warrants the attention of all clinicians because of its serious prognosis. The clinical course of this cutaneous syndrome is similar in children and adults, but some differences do exist. Because diagnostic laboratory tests are not available, the physician must recognize the disorder by its distinctive ...
A J, Ammann, W H, Tooley, R, Hong
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Toxic epidermal necrolysis, although uncommon, warrants the attention of all clinicians because of its serious prognosis. The clinical course of this cutaneous syndrome is similar in children and adults, but some differences do exist. Because diagnostic laboratory tests are not available, the physician must recognize the disorder by its distinctive ...
A J, Ammann, W H, Tooley, R, Hong
+7 more sources
Current Drug Safety, 2012
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Florence, Castelain, Philippe, Humbert
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Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Florence, Castelain, Philippe, Humbert
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Australasian Journal of Dermatology, 1996
SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard ...
J S, Pasricha +4 more
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SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard ...
J S, Pasricha +4 more
openaire +4 more sources
Journal of Burn Care & Rehabilitation, 1997
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
J T, Murphy, G F, Purdue, J L, Hunt
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Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
J T, Murphy, G F, Purdue, J L, Hunt
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Southern Medical Journal, 1964
A DIFFUSE bullous eruption of acute onset associated with marked skin tenderness was described in 1956 by Lyell1 as well as Lang and Walker.2 Subsequently, Beare3 reviewed the literature and described. the clinical and histologic manifestations of 10 cases observed in Irish adults and children.
I M, FREEDBERG, R B, BERG
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A DIFFUSE bullous eruption of acute onset associated with marked skin tenderness was described in 1956 by Lyell1 as well as Lang and Walker.2 Subsequently, Beare3 reviewed the literature and described. the clinical and histologic manifestations of 10 cases observed in Irish adults and children.
I M, FREEDBERG, R B, BERG
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Medical Clinics of North America, 1975
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
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Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
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Dermatologic Clinics, 2000
Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
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Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
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JAMA: The Journal of the American Medical Association, 1965
This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
G, BAILEY, J M, ROSENBAUM, B, ANDERSON
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This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
G, BAILEY, J M, ROSENBAUM, B, ANDERSON
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Archives of Dermatology, 1960
A striking dermatologic disease resembling scalding, namely acute pemphigus, has been recently renamed toxic epidermal necrolysis by Lyell,1or epidermolysis necroticans combustiformis by Soltermann.2Already, mention has been made in the literature of a score or more examples under these names, and the disease is apparently not rare.3However, no recent ...
B, POTTER, R, AUERBACH, A L, LORINCZ
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A striking dermatologic disease resembling scalding, namely acute pemphigus, has been recently renamed toxic epidermal necrolysis by Lyell,1or epidermolysis necroticans combustiformis by Soltermann.2Already, mention has been made in the literature of a score or more examples under these names, and the disease is apparently not rare.3However, no recent ...
B, POTTER, R, AUERBACH, A L, LORINCZ
openaire +2 more sources
Pharmacogenetics of toxic epidermal necrolysis
Expert Opinion on Pharmacotherapy, 2010Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are two of the most severe drug-induced cutaneous reactions. Advances in genome technologies have allowed researchers to identify genetic markers associated with this drug-associated event and these have provided a potential tool for prevention.Current updates of genetic biomarkers ...
Ming Ta Michael, Lee +3 more
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